Pre-clinical evaluation of novel small-molecule GPR119 agonists to treat metabolic disorders

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Pre-clinical evaluation of novel small-molecule GPR119 agonists to treat metabolic disorders

This PhD project investigates the preclinical safety, efficacy, and pharmacokinetics (PK) features of novel GPR119 agonists, ps297 and ps318, for metabolic disorders. Both investigational compounds act as GLP-1 secretagogues, showing synergistic effects with sitagliptin. PK analysis confirmed a gut-...

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Bibliographic Details
Main Author:	Patil, Mohan
Format:	Thesis
Published:	Curtin University 2025
Online Access:	http://hdl.handle.net/20.500.11937/97771

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