Pre-clinical evaluation of novel small-molecule GPR119 agonists to treat metabolic disorders
This PhD project investigates the preclinical safety, efficacy, and pharmacokinetics (PK) features of novel GPR119 agonists, ps297 and ps318, for metabolic disorders. Both investigational compounds act as GLP-1 secretagogues, showing synergistic effects with sitagliptin. PK analysis confirmed a gut-...
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| Format: | Thesis |
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Curtin University
2025
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| Online Access: | http://hdl.handle.net/20.500.11937/97771 |