Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk

QR Code

Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk

Two main risk factors for Alzheimer’s Disease are the APOE4 gene and a diet high in saturated fat. Additionally, the protein amyloid-beta is a primary pathological characteristic of Alzheimer’s Disease. This thesis demonstrates a vascular axis of Alzheimer’s Disease risk. Following a high-fat meal,...

Full description

Bibliographic Details
Main Author:	D'Alonzo, Zachary John
Format:	Thesis
Published:	Curtin University 2025
Online Access:	http://hdl.handle.net/20.500.11937/97724

Similar Items

Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer's disease: potential interactive effects of APOE genotype with dietary fats
by: D'Alonzo, Zachary, et al.
Published: (2023)

Enterocyte Beta Amyloid-Lipoprotein Homeostasis: Implications for Alzheimer's Disease Risk
by: Galloway, Susan
Published: (2015)

Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta
by: Takechi, Ryu, et al.
Published: (2010)

The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid
by: Verdile, Giuseppe, et al.
Published: (2007)

Molecular docking studies on the interaction of anti-alzheimer compounds with amyloid beta peptides
by: Faujan, Nur Hana, et al.
Published: (2019)

Colocalisation of plasma derived apo B lipoproteins with cerebral proteoglycans in a transgenic-amyloid model of Alzheimer's disease
by: Lam, Virginie, et al.
Published: (2011)

Peripheral Metabolism of Lipoprotein-amyloid Beta as a Risk Factor for Diabetes-induced Alzheimer's Disease and the Therapeutic Effects of Probucol and its Analogue
by: Sharif, Arazu
Published: (2024)

Plasma Amyloid-beta as a Biomarker in Alzheimer's Disease: The AIBL Study of Aging
by: Lui, J., et al.
Published: (2010)

Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease
by: Verdile, Giuseppe, et al.
Published: (2014)

Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study
by: Pike, K., et al.
Published: (2011)

ß-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men
by: Holmes, S., et al.
Published: (2016)

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
by: Xie, Ling, et al.
Published: (2002)

Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In Treating Alzheimer’s Disease
by: Mohd Suhaimi, Ahmad Marwazi
Published: (2024)

Effect of fatty acids on enterocytic beta-amyloid abundance: Possible aetiology in Alzheimer’s disease
by: Galloway, S., et al.
Published: (2008)

Dietary fats, cerebrovasculature integrity and Alzheimer's disease risk
by: Takechi, Ryu, et al.
Published: (2010)

Association of Cardiovascular Factors and Alzheimer's Disease Plasma Amyloid-beta Protein in Subjective Memory Complainers
by: bates, K., et al.
Published: (2009)

Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein
by: Bharadwaj, Prashant, et al.
Published: (2018)

The effect of minocycline on novel object recognition memory and beta amyloid protein expression in alzheimer’s disease rat model
by: Poobalan, Kumararoobini
Published: (2016)

Synergistic effects of high fat feeding and apolipoprotein E deletion on enterocytic amyloid-beta abundance.
by: Galloway, Susan, et al.
Published: (2008)

Molecular simulation between amyloid beta (1-42), a Peptide associated with alzheimer disease, and zinc(ii) ion
by: Abdul Ghani, Nur Syafiqah
Published: (2016)

Clearance mechanisms of Alzheimer’s amyloid-b peptide: implications for therapeutic design and diagnostic tests
by: Bates, K., et al.
Published: (2009)

The structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide
by: Malajczuk, Chris
Published: (2022)

Chylomicron amyloi-beta in the aetiology of Alzheimer's disease
by: Takechi, Ryu, et al.
Published: (2008)

Unveiling amyloid-β1–42 interaction with zinc in water and mixed hexafluoroisopropanol solution in Alzheimer’s disease
by: Ghani, Nur Syafiqah Abdul, et al.
Published: (2017)

Plasma lipoprotein b-amyloid in subjects with Alzheimer's disease or mild cognitive impairment
by: Mamo, John, et al.
Published: (2008)

Amyloid-ß and islet amyloid pathologies link Alzheimer disease and type 2 diabetes in a transgenic model.
by: Wijesekara, N., et al.
Published: (2017)

Alzheimer's disease detection combining novel radiogenomics of APOE e, structural and functional MRI
by: Suppiah, Subapriya, et al.
Published: (2024)

Finding chemopreventatives to reduce amyloid beta in yeast
by: Macreadie, I., et al.
Published: (2016)

Probucol Reduces Enterocytic Amyloid-beta Relative to Chylomicron Apolipoprotein B in Mice Chronically Fed Saturated Fats
by: Takechi, Ryu, et al.
Published: (2010)

The differential effects of fatty acids on enterocytic abundance of amyloid-beta
by: Galloway, Susan, et al.
Published: (2019)

Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity
by: Dubey, A., et al.
Published: (2009)

The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism
by: Verdile, Giuseppe, et al.
Published: (2009)

Amyloid-beta colocalizes with apolipoprotein B in absorptive cells of the small intestine
by: Galloway, Susan, et al.
Published: (2009)

Characterising Interactions Between Amyloid-beta 42 and Amylin Peptide Heterodimers: A Molecular Simulation Approach
by: Sonar, Krushna Satish
Published: (2022)

Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE-/- mouse fed a high fat diet
by: Bakker, J., et al.
Published: (2016)

The effect of exogenous cholesterol and lipid-modulating agents on enterocytic amyloid-beta abundance
by: Galloway, Susan, et al.
Published: (2009)

LOW DOSE DIETARY NITRATE IMPROVES ENDOTHELIAL DYSFUNCTION IN THE APOE(-/-) MOUSE
by: Bakker, J., et al.
Published: (2016)

Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients
by: Bebakar, Wan Mohamad Wan
Published: (2001)

Klotho allele status is not associated with Aß and APOE e4–related cognitive decline in preclinical Alzheimer's disease
by: Porter, T., et al.
Published: (2019)

Multitarget drug design strategy in Alzheimer’s disease: focus on cholinergic transmission and amyloid-β aggregation
by: Simioni, Elena, et al.
Published: (2017)