Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk
Two main risk factors for Alzheimer’s Disease are the APOE4 gene and a diet high in saturated fat. Additionally, the protein amyloid-beta is a primary pathological characteristic of Alzheimer’s Disease. This thesis demonstrates a vascular axis of Alzheimer’s Disease risk. Following a high-fat meal,...
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| Format: | Thesis |
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Curtin University
2025
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| Online Access: | http://hdl.handle.net/20.500.11937/97724 |
| _version_ | 1848766309590892544 |
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| author | D'Alonzo, Zachary John |
| author_facet | D'Alonzo, Zachary John |
| author_sort | D'Alonzo, Zachary John |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Two main risk factors for Alzheimer’s Disease are the APOE4 gene and a diet high in saturated fat. Additionally, the protein amyloid-beta is a primary pathological characteristic of Alzheimer’s Disease. This thesis demonstrates a vascular axis of Alzheimer’s Disease risk. Following a high-fat meal, humans exhibited elevated levels of amyloid-beta in the blood, with a further increase observed in individuals carrying the APOE4 gene. Notably, this elevation was more pronounced after the consumption of saturated fats compared to unsaturated fats. |
| first_indexed | 2025-11-14T11:49:06Z |
| format | Thesis |
| id | curtin-20.500.11937-97724 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:49:06Z |
| publishDate | 2025 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-977242025-05-13T01:12:21Z Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk D'Alonzo, Zachary John Two main risk factors for Alzheimer’s Disease are the APOE4 gene and a diet high in saturated fat. Additionally, the protein amyloid-beta is a primary pathological characteristic of Alzheimer’s Disease. This thesis demonstrates a vascular axis of Alzheimer’s Disease risk. Following a high-fat meal, humans exhibited elevated levels of amyloid-beta in the blood, with a further increase observed in individuals carrying the APOE4 gene. Notably, this elevation was more pronounced after the consumption of saturated fats compared to unsaturated fats. 2025 Thesis http://hdl.handle.net/20.500.11937/97724 Curtin University fulltext |
| spellingShingle | D'Alonzo, Zachary John Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk |
| title | Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk |
| title_full | Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk |
| title_fullStr | Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk |
| title_full_unstemmed | Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk |
| title_short | Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk |
| title_sort | interactive effects of dietary fat and apoe genotype on peripheral amyloid-beta: implications for alzheimer’s disease risk |
| url | http://hdl.handle.net/20.500.11937/97724 |