A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders

Consistent with the concept of the gut-brain phenomenon, observational studies suggest a relationship between Alzheimer’s disease (AD) and gastrointestinal tract (GIT) disorders; however, their underlying mechanisms remain unclear. Here, we analyse several genome-wide association studies (GWAS) summ...

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Bibliographic Details
Main Authors: Adewuyi, Emmanuel, O’Brien, E.K., Nyholt, D.R., Porter, T., Laws, S.M.
Format: Journal Article
Language:English
Published: NATURE PORTFOLIO 2022
Subjects:
Science & Technology
Life Sciences & Biomedicine
Biology
Multidisciplinary Sciences
Life Sciences & Biomedicine - Other Topics
Science & Technology - Other Topics
INFLAMMATORY-BOWEL-DISEASE
HELICOBACTER-PYLORI
MENDELIAN RANDOMIZATION
SUSCEPTIBILITY LOCI
GUT-MICROBIOTA
RISK LOCI
ASSOCIATION
METAANALYSIS
THERAPY
AXIS
Alzheimer Disease
Gastroesophageal Reflux
Genome-Wide Association Study
Humans
Membrane Proteins
Nerve Tissue Proteins
Polymorphism, Single Nucleotide
Online Access:http://hdl.handle.net/20.500.11937/97669

Internet

http://hdl.handle.net/20.500.11937/97669

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