Relationship of Cognition and Alzheimer’s Disease with Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap and Mendelian Randomisation Analysis

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Relationship of Cognition and Alzheimer’s Disease with Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap and Mendelian Randomisation Analysis

Emerging observational evidence suggests links between cognitive impairment and a range of gastrointestinal tract (GIT) disorders; however, the mechanisms underlying their relationships remain unclear. Leveraging large-scale genome-wide association studies’ summary statistics, we comprehensively ass...

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Bibliographic Details
Main Authors:	Adewuyi, Emmanuel, O’Brien, E.K., Porter, T., Laws, S.M.
Format:	Journal Article
Language:	English
Published:	MDPI 2022
Subjects:	Science & Technology Life Sciences & Biomedicine Physical Sciences Biochemistry & Molecular Biology Chemistry, Multidisciplinary Chemistry Alzheimer's disease causality cognition cognitive traits educational attainment gastrointestinal tract disorders genome-wide association studies (GWAS) local genetic correlation global genetic correlation Mendelian randomization ASSOCIATION IMPAIRMENT MICROBIOTA Alzheimer’s disease Humans Alzheimer Disease Genome-Wide Association Study Cognition Gastroesophageal Reflux Inflammatory Bowel Diseases Polymorphism, Single Nucleotide
Online Access:	http://hdl.handle.net/20.500.11937/97667

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