Relationship of Cognition and Alzheimer’s Disease with Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap and Mendelian Randomisation Analysis

Relationship of Cognition and Alzheimer’s Disease with Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap and Mendelian Randomisation Analysis

Emerging observational evidence suggests links between cognitive impairment and a range of gastrointestinal tract (GIT) disorders; however, the mechanisms underlying their relationships remain unclear. Leveraging large-scale genome-wide association studies’ summary statistics, we comprehensively ass...

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Bibliographic Details
Main Authors: Adewuyi, Emmanuel, O’Brien, E.K., Porter, T., Laws, S.M.
Format: Journal Article
Language:English
Published: MDPI 2022
Subjects:
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
Alzheimer's disease
causality
cognition
cognitive traits
educational attainment
gastrointestinal tract disorders
genome-wide association studies (GWAS)
local genetic correlation
global genetic correlation
Mendelian randomization
ASSOCIATION
IMPAIRMENT
MICROBIOTA
Alzheimer’s disease
Humans
Alzheimer Disease
Genome-Wide Association Study
Cognition
Gastroesophageal Reflux
Inflammatory Bowel Diseases
Polymorphism, Single Nucleotide
Online Access:http://hdl.handle.net/20.500.11937/97667

Internet

http://hdl.handle.net/20.500.11937/97667

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