Investigating Genetic Overlap between Alzheimer’s Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis

Investigating Genetic Overlap between Alzheimer’s Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis

There is evidence to support a link between abnormal lipid metabolism and Alzheimer’s disease (AD) risk. Similarly, observational studies suggest a comorbid relationship between AD and coronary artery disease (CAD). However, the intricate biological mechanisms of AD are poorly understood, and its re...

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Bibliographic Details
Main Authors: Kirby, A., Porter, T., Adewuyi, Emmanuel, Laws, S.M.
Format: Journal Article
Language:English
Published: 2024
Subjects:
Alzheimer’s disease
Mendelian randomisation
coronary artery disease
gene-based analysis
global genetic correlation
linkage disequilibrium score regression
lipids
local analysis of [co]variant associations
local genetic correlation
Humans
Alzheimer Disease
Coronary Artery Disease
Genome-Wide Association Study
Genetic Predisposition to Disease
Lipids
Lipid Metabolism
Quantitative Trait Loci
Polymorphism, Single Nucleotide
Triglycerides
Online Access:http://hdl.handle.net/20.500.11937/97665

Internet

http://hdl.handle.net/20.500.11937/97665

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