Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats

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Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats

Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of...

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Bibliographic Details
Main Authors:	Hodgetts, S.I., Yoon, J.H., Fogliani, A., Akinpelu, E.A., Baron-Heeris, D., Houwers, I.G.J., Wheeler, L.P.G., Majda, Bernadette T., Santhakumar, S., Lovett, S.J., Duce, E., Pollett, M.A., Wiseman, T.M., Fehily, B., Harvey, A.R.
Format:	Journal Article
Language:	English
Published:	2018
Subjects:	Animals Ciliary Neurotrophic Factor Combined Modality Therapy Dependovirus Female Genetic Therapy Genetic Vectors Mesenchymal Stem Cell Transplantation Nerve Regeneration Rats Rats, Inbred F344 Recovery of Function Spinal Cord Injuries Treatment Outcome
Online Access:	http://hdl.handle.net/20.500.11937/96902

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