Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats

Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats

Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of...

Full description

Bibliographic Details
Main Authors: Hodgetts, S.I., Yoon, J.H., Fogliani, A., Akinpelu, E.A., Baron-Heeris, D., Houwers, I.G.J., Wheeler, L.P.G., Majda, Bernadette T., Santhakumar, S., Lovett, S.J., Duce, E., Pollett, M.A., Wiseman, T.M., Fehily, B., Harvey, A.R.
Format: Journal Article
Language:English
Published: 2018
Subjects:
Animals
Ciliary Neurotrophic Factor
Combined Modality Therapy
Dependovirus
Female
Genetic Therapy
Genetic Vectors
Mesenchymal Stem Cell Transplantation
Nerve Regeneration
Rats
Rats, Inbred F344
Recovery of Function
Spinal Cord Injuries
Treatment Outcome
Online Access:http://hdl.handle.net/20.500.11937/96902

Internet

http://hdl.handle.net/20.500.11937/96902

Similar Items