Skewed X-inactivation is common in the general female population

Skewed X-inactivation is common in the general female population

X-inactivation is a well-established dosage compensation mechanism ensuring that X-chromosomal genes are expressed at comparable levels in males and females. Skewed X-inactivation is often explained by negative selection of one of the alleles. We demonstrate that imbalanced expression of the paterna...

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Main Authors: Shvetsova, E., Sofronova, A., Monajemi, R., Gagalova, Kristina, Draisma, H.H.M., White, S.J., Santen, G.W.E., Chuva de Sousa Lopes, S.M., Heijmans, B.T., van Meurs, J., Jansen, R., Franke, L., Kiełbasa, S.M., den Dunnen, J.T., ‘t Hoen, P.A.C., Boomsma, D.I., Pool, R., van Dongen, J., Hottenga, J.J., van Greevenbroek, M.M., Stehouwer, C.D., van der Kallen, C.J., Schalkwijk, C.G., Wijmenga, C., Zhernakova, S., Tigchelaar, E.F., Slagboom, P.E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J.H., van den Berg, L.H., van Duijn, C.M., Hofman, B.A., Uitterlinden, A.G., Jhamai, P.M., Verbiest, M., Suchiman, H.E.D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., Bot, J., Zhernakova, D.V., van ’t Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Luijk, R., Jan Bonder, M., van Iterson, M., van Dijk, F., van Galen, M., Arindrarto, W., Swertz, M.A., van Zwet, E.W., Isaacs, A., Francioli, L., Menelaou, A., Pulit, S., Palamara, P., Elbers, C., Neerincx, P., Ye, K., Guryev, V., Kloosterman, W., Abdellaoui, A., van Leeuwen, E., van Oven, M., Li, M., Laros, J., Karssen, L., Kanterakis, A., Amin, N., Hottenga, J., Lameijer, E., Kattenberg, M., Dijkstra, M., Byelas, H., van Setten, J., van Schaik, B., Nijman, I., Renkens, I., Marschall, T., Schönhuth, A., Hehir-Kwa, J., Handsaker, R., Polak, P., Sohail, M., Vuzman, D.
Format: Journal Article
Language:English
Published: 2019
Subjects:
Calcium-Binding Proteins
Female
Humans
Intracellular Signaling Peptides and Proteins
Male
Membrane Glycoproteins
Netherlands
Polymorphism, Single Nucleotide
Population
Receptors, Cytoplasmic and Nuclear
Receptors, Peptide
Septins
X Chromosome Inactivation
BIOS consortium
GoNL consortium
Online Access:http://hdl.handle.net/20.500.11937/96875

Internet

http://hdl.handle.net/20.500.11937/96875

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