Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells

Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells

Background: Constitutive activation of signal transducer and activator of transcription signalling 3 (STAT3) has been linked with survival, proliferation and angiogenesis in a wide variety of malignancies including hepatocellular carcinoma (HCC). Methods: We evaluated the effect of lupeol on STAT3 s...

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Bibliographic Details
Main Authors: Siveen, K., Nguyen, A., Lee, J., Li, F., Singh, S., Kumar, Alan Prem, Low, G., Jha, S., Tergaonkar, V., Ahn, K., Sethi, G.
Format: Journal Article
Published: Nature Publishing Group 2014
Subjects:
lupeol
apoptosis
SHP-2
STAT3
hepatocellular carcinoma
Online Access:http://hdl.handle.net/20.500.11937/9603

Internet

http://hdl.handle.net/20.500.11937/9603

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