Understanding the underlying mechanisms behind macrophage dysfunction in the elderly tumour microenvironment
Cancer incidence increases with age which coincides with changes to immune cells, called macrophages. This thesis identified macrophages become dysregulated with ageing to promote tumour growth. Intracellular communication molecules, called mTOR, drive this process and targeting mTOR led to a signif...
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| Format: | Thesis |
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Curtin University
2023
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| Online Access: | http://hdl.handle.net/20.500.11937/95642 |
| _version_ | 1848766036326744064 |
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| author | Duong, Lelinh |
| author_facet | Duong, Lelinh |
| author_sort | Duong, Lelinh |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Cancer incidence increases with age which coincides with changes to immune cells, called macrophages. This thesis identified macrophages become dysregulated with ageing to promote tumour growth. Intracellular communication molecules, called mTOR, drive this process and targeting mTOR led to a significant decrease in tumour growth and enhanced survival amongst elderly hosts. These findings identify a therapeutic avenue to restore immune function and improve outcomes for elderly cancer patients. |
| first_indexed | 2025-11-14T11:44:45Z |
| format | Thesis |
| id | curtin-20.500.11937-95642 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:44:45Z |
| publishDate | 2023 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-956422024-08-05T05:43:54Z Understanding the underlying mechanisms behind macrophage dysfunction in the elderly tumour microenvironment Duong, Lelinh Cancer incidence increases with age which coincides with changes to immune cells, called macrophages. This thesis identified macrophages become dysregulated with ageing to promote tumour growth. Intracellular communication molecules, called mTOR, drive this process and targeting mTOR led to a significant decrease in tumour growth and enhanced survival amongst elderly hosts. These findings identify a therapeutic avenue to restore immune function and improve outcomes for elderly cancer patients. 2023 Thesis http://hdl.handle.net/20.500.11937/95642 Curtin University restricted |
| spellingShingle | Duong, Lelinh Understanding the underlying mechanisms behind macrophage dysfunction in the elderly tumour microenvironment |
| title | Understanding the underlying mechanisms behind macrophage dysfunction in the elderly tumour microenvironment |
| title_full | Understanding the underlying mechanisms behind macrophage dysfunction in the elderly tumour microenvironment |
| title_fullStr | Understanding the underlying mechanisms behind macrophage dysfunction in the elderly tumour microenvironment |
| title_full_unstemmed | Understanding the underlying mechanisms behind macrophage dysfunction in the elderly tumour microenvironment |
| title_short | Understanding the underlying mechanisms behind macrophage dysfunction in the elderly tumour microenvironment |
| title_sort | understanding the underlying mechanisms behind macrophage dysfunction in the elderly tumour microenvironment |
| url | http://hdl.handle.net/20.500.11937/95642 |