Albumin-drug interaction and its clinical implication

QR Code

Albumin-drug interaction and its clinical implication

Background: Human serum albumin acts as a reservoir and transport protein for endogenous (e.g. fatty acids or bilirubin) and exogenous compounds (e.g. drugs or nutrients) in the blood. The binding of a drug to albumin is a major determinant of its pharmacokinetic and pharmacodynamic profile.Scope of...

Full description

Bibliographic Details
Main Authors:	Yamasaki, K., Maruyama, T., Chuang, Victor, Otagiri, M.
Format:	Journal Article
Published:	Elsevier BV 2013
Subjects:	Displacement Structure–function relationship Human serum albumin Extracorporeal albumin dialysis Binding site
Online Access:	http://hdl.handle.net/20.500.11937/9478

Similar Items

Stereoselective Binding of Human Serum Albumin
by: Chuang, Victor, et al.
Published: (2006)

Practical Aspects of the Ligand-Binding and Enzymatic Properties of Human Serum Albumin
by: Kragh-Hansen, U., et al.
Published: (2002)

Flunitrazepam, a 7-nitro-1,4-benzodiazepine that is unable to bind to the indole-benzodiazepine site of human serum albumin
by: Chuang, Victor, et al.
Published: (2001)

How Do Fatty Acids Cause Allosteric Binding of Drugs to Human Serum Albumin?
by: Chuang, Victor, et al.
Published: (2002)

Redox properties of serum albumin
by: Anraku, M., et al.
Published: (2013)

Development of halal plant-based hydrocolloids encapsulation for targeted delivery of bovine serum albumin
by: Mohamed, Hajaratul Najwa
Published: (2015)

Histidine146 of Human Serum Albumin Plays a Prominent Role at the Interface of Subdomains IA and IIA in Allosteric Ligand Binding
by: Kaneko, K., et al.
Published: (2011)

Characterisation of bovine serum albumin-based biomaterials synthesised by subcritical water technology
by: Esfahan, Zahra Maghareh
Published: (2019)

Part A: Outlining the current state of AAVs & evaluating albumins potential role in AAV stability / Part B: Comparing separation resolution of multiple SEC columns & evaluating AAV-albumin interactions
by: Hughes, Oliver
Published: (2024)

Drug-loaded hydrogel microneedles for sustainable transdermal delivery of macromolecular proteins
by: Chandran, Rubhan, et al.
Published: (2025)

Photoaffinity labeling of plasma proteins
by: Chuang, Victor, et al.
Published: (2013)

Preparation of a Monolith with Covalently Bound Bovine Serum Albumin for Capillary Electrochromatography
by: Yao, C., et al.
Published: (2012)

Understanding the role of serum albumin on the regulation of drug uptake transporters in the liver
by: Kanwar, Nisha
Published: (2025)

Helix 6 of subdomain III A of human serum albumin is the region primarily photolabeled by ketoprofen, an arylpropionic acid NSAID containing a benzophenone moiety
by: Chuang, Victor, et al.
Published: (1999)

Purification and characterization of polyclonal anti-hepatitis B core antigen immunoglobulin G from rabbit serum
by: Sayed Hitam, Sharifah Mariam
Published: (2016)

Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding
by: Purdie, Laura, et al.
Published: (2018)

Part A: The stability of Adenoviral and mRNA based COVID-19 vaccines and the potential of HSA/ Part B: Characterisation of IgG A33 hFab’ and human serum albumin using hydrodynamic methods
by: Abu Hammad, Khalil
Published: (2021)

Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults
by: Lam, Virginie, et al.
Published: (2014)

Stripping voltammetric detection of insulin at liquid–liquid microinterfaces in the presence of bovine albumin
by: O'Sullivan, S., et al.
Published: (2013)

Evaluation of tween 80 incorporated media to increase pathogen isolation from peritoneal fluid of CAPD patients at a public hospital in Kuala Lumpur, Malaysia
by: Ganapathy Pillay, Stella
Published: (2020)

Effects of ground flaxseed supplementation on cardiovascular disease among hemodialysis patients at a goverment hospital in Tehran, Iran
by: Soltani, Saman Khalatbari
Published: (2013)

Effects of ground flaxseed supplementation on cardiovascular disease among hemodialysis patients at a goverment hospital, in Tehran, Iran
by: Soltani, Saman Khalatbari
Published: (2013)

Metabolic signature of protein energy wasting among Malaysian hemodialysis patients
by: Pauzi, Fatin Athirah
Published: (2020)

The potential of a cross-linked human serum albumin dimer in diabetic rats as an augmenting agent for antidiabetic drugs
by: Taguchi, K., et al.
Published: (2015)

Factors associated with food choice values among older hemodialysis patients in selected dialysis centres in Selangor, Malaysia
by: Mohd Shahrin, Fatin Izzaty
Published: (2019)

Recombinant human serum albumin
by: Chuang, Victor, et al.
Published: (2007)

Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin
by: Yamasaki, K., et al.
Published: (2017)

Pharmacokinetically modified human serum albumin based therapeutic design and development
by: Taguchi, K., et al.
Published: (2015)

Subdomain IIIA of Dog Albumin Contains a Binding Site Similar to Site II of Human Albumin
by: Kaneko, K., et al.
Published: (2008)

Development and validation of food frequency questionnaire for urban hemodialysis population in selected dialysis centres at the Klang Valley, Malaysia
by: Md Ali, Mohammad Syafiq
Published: (2020)

On hydrodynamic methods for the analysis of the sizes and shapes of polysaccharides in dilute solution: a short review
by: Morris, Gordon A., et al.
Published: (2014)

Structural Investigation of Zn2+ ions, FXII and Complement receptor gC1q-R interaction: Triggering the Contact activation System
by: Kaira, Bubacarr
Published: (2019)

Correlation between socio-demographic, nutritional and clinical markers and poor sleep quality among hemodialysis patients in Sibu, Sarawak, Malaysia
by: Ho, Lina Ling Ling
Published: (2018)

Potential use of human serum albumin as a drug delivery systems
by: Ishima, Y., et al.
Published: (2015)

Pharmaceutical Aspects of the Recombinant Human Serum Albumin Dimer: Structural Characteristics, Biological Properties, and Medical Applications
by: Taguchi, K., et al.
Published: (2012)

Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets
by: Cox, Megan H., et al.
Published: (2018)

Pharmaceutically Important Pre- and Posttranslational Modifications on Human Serum Albumin
by: Otagiri, M., et al.
Published: (2009)

Epidemiology of dialysis-treated end-stage kidney disease in adults in Libya
by: Alashek, Wiam Abdulaziz.
Published: (2013)

Cost-shifting of dialysis treatment in Western Australia: Winners and losers
by: Mangano, Maria
Published: (2009)

Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
by: Li, Wenlong, et al.
Published: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ol4usadj8dptjkknlfh2glp9ip