The differential effects of fatty acids on enterocytic abundance of amyloid-beta
Background: Consumption of a Western-styled diet enriched in saturated fatty acids (SFA) relative to polyunsaturated fatty acids is positively associated with risk for Alzheimer's disease. Whilst potential causal mechanism are unclear, there is increasing evidence that chronic ingestion of SFA...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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BMC
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/94244 |
| _version_ | 1848765851534098432 |
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| author | Galloway, Susan Takechi, Ryu Nesbit, Michael Pallebage-Gamarallage, Menuka M. Lam, Virginie Mamo, John |
| author_facet | Galloway, Susan Takechi, Ryu Nesbit, Michael Pallebage-Gamarallage, Menuka M. Lam, Virginie Mamo, John |
| author_sort | Galloway, Susan |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Consumption of a Western-styled diet enriched in saturated fatty acids (SFA) relative to polyunsaturated fatty acids is positively associated with risk for Alzheimer's disease. Whilst potential causal mechanism are unclear, there is increasing evidence that chronic ingestion of SFA enriched diets promote increase the plasma levels of lipoprotein-associated amyloid-β (Aβ). However, the effects of dietary mono- and poly-unsaturated fats (MUFA/PUFA) on nascent lipoprotein Aβ abundance have not been previously reported. Methods: Wild-type C57BL/6 J mice were maintained on low-fat control chow (LF) or diets enriched in either SFA, MUFA, or PUFA for 9 months. Enterocytic abundance of Aβ was determined with quantitative immunofluorescent microscopy and plasma Aβ was measured by ELISA. Results: The chronic ingestion of SFA-enriched diet increased the enterocytic abundance and plasma concentration of Aβ compared to LF control mice. The mice maintained on MUFA or PUFA diet showed comparable enterocytic and plasma Aβ levels to the LF control mice. Conclusions: The data indicates that a diet enriched in SFA significantly increases the enterocytic Aβ production and secretion into the circulation, whilst MUFA and PUFA enriched diet do not exert such effects. |
| first_indexed | 2025-11-14T11:41:49Z |
| format | Journal Article |
| id | curtin-20.500.11937-94244 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:41:49Z |
| publishDate | 2019 |
| publisher | BMC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-942442024-02-06T05:26:12Z The differential effects of fatty acids on enterocytic abundance of amyloid-beta Galloway, Susan Takechi, Ryu Nesbit, Michael Pallebage-Gamarallage, Menuka M. Lam, Virginie Mamo, John Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Nutrition & Dietetics Amyloid-beta Dietary intervention Enterocytes Saturated fatty acids Small intestine Unsaturated fatty acids ALZHEIMERS-DISEASE COLOCALIZATION JAPANESE PROTEIN CELLS MEN AD Amyloid-β Dietary intervention Enterocytes Saturated fatty acids Small intestine Unsaturated fatty acids Amyloid beta-Peptides Animals Dietary Fats Enterocytes Enzyme-Linked Immunosorbent Assay Fatty Acids Fatty Acids, Monounsaturated Fatty Acids, Unsaturated Female Intestine, Small Mice Mice, Inbred C57BL Enterocytes Intestine, Small Animals Mice, Inbred C57BL Mice Dietary Fats Fatty Acids Fatty Acids, Unsaturated Fatty Acids, Monounsaturated Enzyme-Linked Immunosorbent Assay Female Amyloid beta-Peptides Background: Consumption of a Western-styled diet enriched in saturated fatty acids (SFA) relative to polyunsaturated fatty acids is positively associated with risk for Alzheimer's disease. Whilst potential causal mechanism are unclear, there is increasing evidence that chronic ingestion of SFA enriched diets promote increase the plasma levels of lipoprotein-associated amyloid-β (Aβ). However, the effects of dietary mono- and poly-unsaturated fats (MUFA/PUFA) on nascent lipoprotein Aβ abundance have not been previously reported. Methods: Wild-type C57BL/6 J mice were maintained on low-fat control chow (LF) or diets enriched in either SFA, MUFA, or PUFA for 9 months. Enterocytic abundance of Aβ was determined with quantitative immunofluorescent microscopy and plasma Aβ was measured by ELISA. Results: The chronic ingestion of SFA-enriched diet increased the enterocytic abundance and plasma concentration of Aβ compared to LF control mice. The mice maintained on MUFA or PUFA diet showed comparable enterocytic and plasma Aβ levels to the LF control mice. Conclusions: The data indicates that a diet enriched in SFA significantly increases the enterocytic Aβ production and secretion into the circulation, whilst MUFA and PUFA enriched diet do not exert such effects. 2019 Journal Article http://hdl.handle.net/20.500.11937/94244 10.1186/s12944-019-1162-9 English http://creativecommons.org/licenses/by/4.0/ BMC fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Nutrition & Dietetics Amyloid-beta Dietary intervention Enterocytes Saturated fatty acids Small intestine Unsaturated fatty acids ALZHEIMERS-DISEASE COLOCALIZATION JAPANESE PROTEIN CELLS MEN AD Amyloid-β Dietary intervention Enterocytes Saturated fatty acids Small intestine Unsaturated fatty acids Amyloid beta-Peptides Animals Dietary Fats Enterocytes Enzyme-Linked Immunosorbent Assay Fatty Acids Fatty Acids, Monounsaturated Fatty Acids, Unsaturated Female Intestine, Small Mice Mice, Inbred C57BL Enterocytes Intestine, Small Animals Mice, Inbred C57BL Mice Dietary Fats Fatty Acids Fatty Acids, Unsaturated Fatty Acids, Monounsaturated Enzyme-Linked Immunosorbent Assay Female Amyloid beta-Peptides Galloway, Susan Takechi, Ryu Nesbit, Michael Pallebage-Gamarallage, Menuka M. Lam, Virginie Mamo, John The differential effects of fatty acids on enterocytic abundance of amyloid-beta |
| title | The differential effects of fatty acids on enterocytic abundance of amyloid-beta |
| title_full | The differential effects of fatty acids on enterocytic abundance of amyloid-beta |
| title_fullStr | The differential effects of fatty acids on enterocytic abundance of amyloid-beta |
| title_full_unstemmed | The differential effects of fatty acids on enterocytic abundance of amyloid-beta |
| title_short | The differential effects of fatty acids on enterocytic abundance of amyloid-beta |
| title_sort | differential effects of fatty acids on enterocytic abundance of amyloid-beta |
| topic | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Nutrition & Dietetics Amyloid-beta Dietary intervention Enterocytes Saturated fatty acids Small intestine Unsaturated fatty acids ALZHEIMERS-DISEASE COLOCALIZATION JAPANESE PROTEIN CELLS MEN AD Amyloid-β Dietary intervention Enterocytes Saturated fatty acids Small intestine Unsaturated fatty acids Amyloid beta-Peptides Animals Dietary Fats Enterocytes Enzyme-Linked Immunosorbent Assay Fatty Acids Fatty Acids, Monounsaturated Fatty Acids, Unsaturated Female Intestine, Small Mice Mice, Inbred C57BL Enterocytes Intestine, Small Animals Mice, Inbred C57BL Mice Dietary Fats Fatty Acids Fatty Acids, Unsaturated Fatty Acids, Monounsaturated Enzyme-Linked Immunosorbent Assay Female Amyloid beta-Peptides |
| url | http://hdl.handle.net/20.500.11937/94244 |