Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening

Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening

Nowadays identification of novel non-peptide β-secretase (BACE-1, hereinafter) inhibitors with low cytotoxicity and good blood–brain barrier (BBB) property holds common interest of drug discovery for Alzheimer’s disease. Twenty SPECS compounds were tested in BACE-1 FRET assays and methylthiazoletetr...

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Bibliographic Details
Main Authors: Xu, W., Chen, G., Zhu, W., Zuo, Zhili
Format: Journal Article
Published: Pergamon 2010
Subjects:
FRET
Virtual screening
Bioassay
BACE-1
Online Access:http://hdl.handle.net/20.500.11937/9340

Internet

http://hdl.handle.net/20.500.11937/9340

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