A study protocol for the N-ICE trial: A randomised double-blind placebo-controlled study of the safety and efficacy of N-acetyl-cysteine (NAC) as a pharmacotherapy for methamphetamine ("ice") dependence

A study protocol for the N-ICE trial: A randomised double-blind placebo-controlled study of the safety and efficacy of N-acetyl-cysteine (NAC) as a pharmacotherapy for methamphetamine ("ice") dependence

Background: There are currently no approved pharmacotherapies for managing methamphetamine dependence. N-acetylcysteine (NAC) has been found to reduce the craving for methamphetamine and other drugs, but its effect on methamphetamine use and other clinically related endpoints are uncertain. The N-IC...

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Bibliographic Details
Main Authors: McKetin, Rebecca, Dean, O.M., Turner, A., Kelly, P.J., Quinn, B., Lubman, D.I., Dietze, Paul, Carter, G., Higgs, Peter, Baker, A.L., Sinclair, B., Reid, D., Manning, V., Te Pas, N., Liang, Wenbin, Thomas, T., Bathish, R., Kent, M., Raftery, D., Arunogiri, S., Cordaro, F., Hill, H., Berk, M.
Format: Journal Article
Language:English
Published: BMC 2019
Subjects:
Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
substance use disorders
methamphetamine
N-acetylcysteine
clinical trial
craving
withdrawal
psychosis
aggression
depression
suicide
SUBSTANCE USE DISORDERS
PSYCHOMETRIC PROPERTIES
DOPAMINE TRANSPORTERS
ABUSE TREATMENT
SCALE SDS
ACETYLCYSTEINE
COCAINE
RELIABILITY
VALIDATION
VALIDITY
Acetylcysteine
Adolescent
Adult
Amphetamine-Related Disorders
Australia
Central Nervous System Stimulants
Clinical Trials, Phase II as Topic
Craving
Double-Blind Method
Female
Humans
Male
Methamphetamine
Middle Aged
Multicenter Studies as Topic
Randomized Controlled Trials as Topic
Substance Abuse, Intravenous
Time Factors
Treatment Outcome
Young Adult
Online Access:http://purl.org/au-research/grants/nhmrc/1128147
http://hdl.handle.net/20.500.11937/91322

Internet

http://purl.org/au-research/grants/nhmrc/1128147
http://hdl.handle.net/20.500.11937/91322

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