Design, synthesis and antimycobacterial evaluation of novel adamantane and adamantanol analogues effective against drug-resistant tuberculosis

Design, synthesis and antimycobacterial evaluation of novel adamantane and adamantanol analogues effective against drug-resistant tuberculosis

The treacherous nature of tuberculosis (TB) combined with the ubiquitous presence of the drug-resistant (DR) forms pose this disease as a growing public health menace. Therefore, it is imperative to develop new chemotherapeutic agents with a novel mechanism of action to circumvent the cross-resistan...

Full description

Bibliographic Details
Main Authors: Alsayed, S.S.R., Lun, S., Payne, Alan, Bishai, W.R., Gunosewoyo, Hendra
Format: Journal Article
Language:English
Published: ACADEMIC PRESS INC ELSEVIER SCIENCE 2021
Subjects:
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Organic
Chemistry
Tuberculosis
MmpL3
Indoleamides
Adamantane
Adamantanol
MDR-TB
XDR-TB
Cytotoxicity
Water solubility
MYCOLIC ACID TRANSPORT
MYCOBACTERIUM-TUBERCULOSIS
MULTIDRUG-RESISTANT
BIOLOGICAL EVALUATION
MEMBRANE TRANSPORTER
CELL-WALL
MMPL3
DISCOVERY
TARGETS
DERIVATIVES
Antitubercular Agents
Dose-Response Relationship, Drug
Drug Design
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Mycobacterium tuberculosis
Structure-Activity Relationship
Tuberculosis, Multidrug-Resistant
Online Access:http://purl.org/au-research/grants/arc/DE160100482
http://hdl.handle.net/20.500.11937/90998

Internet

http://purl.org/au-research/grants/arc/DE160100482
http://hdl.handle.net/20.500.11937/90998

Similar Items