Facile synthesis and antimycobacterial activity of isoniazid, pyrazinamide and ciprofloxacin derivatives

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Facile synthesis and antimycobacterial activity of isoniazid, pyrazinamide and ciprofloxacin derivatives

Several rationally designed isoniazid (INH), pyrazinamide (PZA) and ciprofloxacin (CPF) derivatives were conveniently synthesized and evaluated in vitro against H37Rv Mycobacterium tuberculosis (M. tb) strain. CPF derivative 16 displayed a modest activity (MIC = 16 µg/ml) and was docked into the M....

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Bibliographic Details
Main Authors:	Alsayed, Shahinda S.R., Lun, S., Payne, Alan, Bishai, William R., Gunosewoyo, Hendra
Format:	Journal Article
Language:	English
Published:	WILEY 2021
Subjects:	Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Chemistry, Medicinal Pharmacology & Pharmacy ciprofloxacin hybrid molecules indoleamides isoniazid pyrazinamide tuberculosis Animals Antitubercular Agents Binding Sites Catalytic Domain Cell Survival Chlorocebus aethiops Ciprofloxacin DNA Gyrase Drug Design Drug Resistance, Bacterial Isoniazid Microbial Sensitivity Tests Molecular Conformation Molecular Docking Simulation Mycobacterium tuberculosis Nontuberculous Mycobacteria Pyrazinamide Structure-Activity Relationship Vero Cells
Online Access:	http://purl.org/au-research/grants/arc/DE160100482 http://hdl.handle.net/20.500.11937/90990

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