Facile synthesis and antimycobacterial activity of isoniazid, pyrazinamide and ciprofloxacin derivatives

Facile synthesis and antimycobacterial activity of isoniazid, pyrazinamide and ciprofloxacin derivatives

Several rationally designed isoniazid (INH), pyrazinamide (PZA) and ciprofloxacin (CPF) derivatives were conveniently synthesized and evaluated in vitro against H37Rv Mycobacterium tuberculosis (M. tb) strain. CPF derivative 16 displayed a modest activity (MIC = 16 µg/ml) and was docked into the M....

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Bibliographic Details
Main Authors: Alsayed, Shahinda S.R., Lun, S., Payne, Alan, Bishai, William R., Gunosewoyo, Hendra
Format: Journal Article
Language:English
Published: WILEY 2021
Subjects:
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Chemistry, Medicinal
Pharmacology & Pharmacy
ciprofloxacin
hybrid molecules
indoleamides
isoniazid
pyrazinamide
tuberculosis
Animals
Antitubercular Agents
Binding Sites
Catalytic Domain
Cell Survival
Chlorocebus aethiops
Ciprofloxacin
DNA Gyrase
Drug Design
Drug Resistance, Bacterial
Isoniazid
Microbial Sensitivity Tests
Molecular Conformation
Molecular Docking Simulation
Mycobacterium tuberculosis
Nontuberculous Mycobacteria
Pyrazinamide
Structure-Activity Relationship
Vero Cells
Online Access:http://purl.org/au-research/grants/arc/DE160100482
http://hdl.handle.net/20.500.11937/90990

Internet

http://purl.org/au-research/grants/arc/DE160100482
http://hdl.handle.net/20.500.11937/90990

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