Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules

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Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules

We previously reported a series of coumestans−a naturally occurring tetracyclic scaffold containing a δ-lactone−that effectively target the thioesterase domain of polyketide synthase 13 (Pks13) in Mycobacterium tuberculosis (Mtb), resulting in superior anti-tuberculosis (TB) activity. Compared to th...

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Bibliographic Details
Main Authors:	Zhang, W., Liu, L.L., Lun, S., Wang, S.S., Xiao, S., Gunosewoyo, Hendra, Yang, F., Tang, J., Bishai, W.R., Yu, L.F.
Format:	Journal Article
Language:	English
Published:	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER 2021
Subjects:	Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy Polyketide synthase 13 conformationally rigid tetracyclics Antitubercular agents Antitubercular Agents Bacterial Proteins Dose-Response Relationship, Drug Drug Design Enzyme Inhibitors Microbial Sensitivity Tests Models, Molecular Molecular Structure Mycobacterium tuberculosis Polyketide Synthases Quinolones Structure-Activity Relationship
Online Access:	http://purl.org/au-research/grants/arc/DE160100482 http://hdl.handle.net/20.500.11937/90987

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