Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules

Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules

We previously reported a series of coumestans−a naturally occurring tetracyclic scaffold containing a δ-lactone−that effectively target the thioesterase domain of polyketide synthase 13 (Pks13) in Mycobacterium tuberculosis (Mtb), resulting in superior anti-tuberculosis (TB) activity. Compared to th...

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Bibliographic Details
Main Authors: Zhang, W., Liu, L.L., Lun, S., Wang, S.S., Xiao, S., Gunosewoyo, Hendra, Yang, F., Tang, J., Bishai, W.R., Yu, L.F.
Format: Journal Article
Language:English
Published: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER 2021
Subjects:
Science & Technology
Life Sciences & Biomedicine
Chemistry, Medicinal
Pharmacology & Pharmacy
Polyketide synthase 13
conformationally rigid tetracyclics
Antitubercular agents
Antitubercular Agents
Bacterial Proteins
Dose-Response Relationship, Drug
Drug Design
Enzyme Inhibitors
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Mycobacterium tuberculosis
Polyketide Synthases
Quinolones
Structure-Activity Relationship
Online Access:http://purl.org/au-research/grants/arc/DE160100482
http://hdl.handle.net/20.500.11937/90987

Internet

http://purl.org/au-research/grants/arc/DE160100482
http://hdl.handle.net/20.500.11937/90987

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