Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan

Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan

Changes in the rate and fidelity of mitochondrial protein synthesis impact the metabolic and physiological roles of mitochondria. Here we explored how environmental stress in the form of a high-fat diet modulates mitochondrial translation and affects lifespan in mutant mice with error-prone (Mrps12e...

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Bibliographic Details
Main Authors: Richman, T.R., Ermer, J.A., Siira, S.J., Kuznetsova, I., Brosnan, C.A., Rossetti, G., Baker, J., Perks, K.L., Cserne Szappanos, H., Viola, H.M., Gray, N., Larance, M., Hool, L.C., Zuryn, S., Rackham, Oliver, Filipovska, A.
Format: Journal Article
Language:English
Published: WILEY 2021
Subjects:
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Geriatrics & Gerontology
ageing
metabolism
mitochondria
protein synthesis
SIRT3
Online Access:http://purl.org/au-research/grants/arc/DP180101656
http://hdl.handle.net/20.500.11937/90821

Internet

http://purl.org/au-research/grants/arc/DP180101656
http://hdl.handle.net/20.500.11937/90821

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