Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of Mycobacterium tuberculosis and paediatric brain tumour cells

Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of Mycobacterium tuberculosis and paediatric brain tumour cells

The omnipresent threat of tuberculosis (TB) and the scant treatment options thereof necessitate the development of new antitubercular agents, preferably working via a novel mechanism of action distinct from the current drugs. Various studies identified the mycobacterial membrane protein large 3 tran...

Full description

Bibliographic Details
Main Authors: Alsayed, Shahinda S.R., Lun, S., Bailey, A.W., Suri, A., Huang, C.C., Mocerino, Mauro, Payne, Alan, Sredni, S.T., Bishai, W.R., Gunosewoyo, Hendra
Format: Journal Article
Language:English
Published: ROYAL SOC CHEMISTRY 2021
Subjects:
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
MYCOLIC ACID TRANSPORT
MEMBRANE TRANSPORTER
DRUG DISCOVERY
NERVOUS-SYSTEM
GLIAL-CELLS
ANTITUBERCULOSIS
ANTICANCER
RESISTANT
MMPL3
ANTIMYCOBACTERIAL
Online Access:http://purl.org/au-research/grants/arc/DE160100482
http://hdl.handle.net/20.500.11937/90753

Internet

http://purl.org/au-research/grants/arc/DE160100482
http://hdl.handle.net/20.500.11937/90753

Similar Items