Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution

Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution

Sec14-superfamily proteins integrate the lipid metabolome with phosphoinositide synthesis and signaling via primed presentation of phosphatidylinositol (PtdIns) to PtdIns kinases. Sec14 action as a PtdIns-presentation scaffold requires heterotypic exchange of phosphatidylcholine (PtdCho) for PtdIns,...

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Bibliographic Details
Main Authors: Schaaf, G., Dynowski, M., Mousley, Carl, Shah, S., Yuan, P., Winklbauer, E., De Campos, M., Trettin, K., Quinones, M., Smirnova, T., Yanagisawa, L., Ortlund, E., Bankaitis, V.
Format: Journal Article
Published: 2011
Online Access:http://hdl.handle.net/20.500.11937/9005

Internet

http://hdl.handle.net/20.500.11937/9005

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