Purine isosters in design and development of novel xanthin oxidase inhibitors
This research focuses on the discovery of novel inhibitors of the enzyme xanthine oxidase to assist in the treatment of hyperuricemia and gout. Four different libraries of compounds with a total of 95 molecules were synthesized, purified, characterized and tested in-vitro, with additional molecular...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Published: |
Curtin University
2022
|
| Online Access: | http://hdl.handle.net/20.500.11937/89687 |
| _version_ | 1848765270755115008 |
|---|---|
| author | Luna, Giuseppe |
| author_facet | Luna, Giuseppe |
| author_sort | Luna, Giuseppe |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This research focuses on the discovery of novel inhibitors of the enzyme xanthine oxidase to assist in the treatment of hyperuricemia and gout. Four different libraries of compounds with a total of 95 molecules were synthesized, purified, characterized and tested in-vitro, with additional molecular docking conducted to rationalize binding interactions. The most active compound was more than 900 times more effective in-vitro than Allopurinol, the current drug of first choice in the market. |
| first_indexed | 2025-11-14T11:32:35Z |
| format | Thesis |
| id | curtin-20.500.11937-89687 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:32:35Z |
| publishDate | 2022 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-896872025-01-15T03:55:24Z Purine isosters in design and development of novel xanthin oxidase inhibitors Luna, Giuseppe This research focuses on the discovery of novel inhibitors of the enzyme xanthine oxidase to assist in the treatment of hyperuricemia and gout. Four different libraries of compounds with a total of 95 molecules were synthesized, purified, characterized and tested in-vitro, with additional molecular docking conducted to rationalize binding interactions. The most active compound was more than 900 times more effective in-vitro than Allopurinol, the current drug of first choice in the market. 2022 Thesis http://hdl.handle.net/20.500.11937/89687 Curtin University fulltext |
| spellingShingle | Luna, Giuseppe Purine isosters in design and development of novel xanthin oxidase inhibitors |
| title | Purine isosters in design and development of novel xanthin oxidase inhibitors |
| title_full | Purine isosters in design and development of novel xanthin oxidase inhibitors |
| title_fullStr | Purine isosters in design and development of novel xanthin oxidase inhibitors |
| title_full_unstemmed | Purine isosters in design and development of novel xanthin oxidase inhibitors |
| title_short | Purine isosters in design and development of novel xanthin oxidase inhibitors |
| title_sort | purine isosters in design and development of novel xanthin oxidase inhibitors |
| url | http://hdl.handle.net/20.500.11937/89687 |