Stability of benzylpenicillin for continuous intravenous infusions: An isotonic formulation for therapeutic use and a low-dose formulation for clinical trial

QR Code

Stability of benzylpenicillin for continuous intravenous infusions: An isotonic formulation for therapeutic use and a low-dose formulation for clinical trial

Introduction: The objectives of this study were to develop a stability-indicating high performance liquid chromatography (HPLC) assay for benzylpenicillin (BPC) in pharmaceutical fluids, and to investigate the stability of (i) isotonic citrate-buffered BPC solutions at the clinically relevant concen...

Full description

Bibliographic Details
Main Authors:	Batty, Kevin, Page-Sharp, Madhu, Salman, S., Hla, T.K., Manning, L.
Format:	Journal Article
Language:	English
Published:	2022
Subjects:	Benzylpenicillin HPLC (High-performance liquid chromatography) Intravenous infusion Sodium citrate Stability Drug Stability Humans Hypertonic Solutions Infusions, Intravenous Isotonic Solutions Penicillin G Sodium Citrate Temperature
Online Access:	http://hdl.handle.net/20.500.11937/88953

Similar Items

An investigation of the stability of meropenem in elastomeric infusion devices
by: Foy, F., et al.
Published: (2019)

Investigation into the effect of formulation on intravenous lipid emulsion metabolism using a novel in vitro fluorescent assay
by: Dougall, Paul W.R.
Published: (2016)

Citric Acid Fermentation by Locally Isolated Aspergillus Niger M2sg1-Ms4
by: Mohd Noor, Noorollhamezon
Published: (2004)

Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration
by: Negm, Ola H., et al.
Published: (2017)

Development of cordycepin formulations for preclinical and clinical studies
by: Lee, Jong Bong, et al.
Published: (2017)

Enhancing the recovery of oilseed rape seed oil bodies (oleosomes) using bicarbonate-based soaking and grinding media
by: De Chirico, Simone, et al.
Published: (2018)

A 23Na NMR study on the environment and mobility of sodium ions in complex food matrices and model systems
by: Shao, Jiaqian
Published: (2019)

Fresh frozen cadavers in surgical teaching: a gelatine arterial infusion technique
by: Jansen, Shirley, et al.
Published: (2011)

Development and characterization of parenteral nano-delivery system loaded with azithromycin
by: Daood, Ghaidaa S
Published: (2016)

Stability of Pentoxifylline Injection: Application to Neonatal/Pediatric Care Setting
by: Senarathna, S.M.D.K.G., et al.
Published: (2021)

Fermentation of Pineapple Taste Juice for the Production of Citric Acid Using Candida Lipolytica ATCC 8661
by: Koshy, Joyce
Published: (1990)

Modelling VARTM process induced variations on bending performance of composite Omega beams
by: Zeng, Xuesen, et al.
Published: (2016)

The processing of hierarchical nanocomposites
by: Umer, R., et al.
Published: (2015)

The effect of sodium on cardio-respiratory health
by: Pogson, Zara
Published: (2009)

Factors influencing the rate of degradation of Amoxycillin sodium and potassium clavulanate in the liquid and frozen states.
by: Vahdat, Laleh
Published: (2000)

A note on the relationship between the isotone assumption of the Abian-Brown fixed point theorem and Abian’s most basic fixed point theorem
by: Luckraz, Shravan
Published: (2014)

A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection
by: Negm, Ola H., et al.
Published: (2018)

Tea flavour : delivery and perception
by: Wright, Jonathan P.
Published: (2007)

A regional citrate anticoagulation protocol for pre-dilutional CVVHDf: The 'Modified Alabama Protocol'
by: Davies, Hugh, et al.
Published: (2008)

Membrane performance and build-up of solute during small scale reverse osmosis operation
by: Nasir, Subriyer
Published: (2007)

Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis
by: Smyth, Alan R., et al.
Published: (2014)

Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome
by: Amer, Saad A., et al.
Published: (2017)

Investigating the effects of an oral fructose challenge on hepatic ATP reserves in healthy volunteers: a 31P MRS study
by: Bawden, Stephen, et al.
Published: (2015)

Stability analysis in stagnation-point flow towards a shrinking sheet with homogeneous - heterogeneous reactions and suction effects
by: Ismail, Nurul Syuhada, et al.
Published: (2016)

Optimisation of octinyl succinic anhydride starch stablised w1/o/w2 emulsions for oral destablisation of encapsulated salt and enhanced saltiness
by: Chiu, Natalie, et al.
Published: (2017)

Investigation of patient blood management in colorectal surgery
by: Keeler, Barrie D.
Published: (2016)

Molecular actions of pyrethroids on ion channels in the maize weevil, Sitophilus zeamais
by: Araújo, Rúbia Aparecida de
Published: (2010)

Biodegradation of Sodium Dodecyl Sulphate by a Locally Isolated Bacterium, Klebsiella Oxytoca Dr.Y14
by: Wan Husin, Wan Surini
Published: (2006)

Quality of benzathine penicillin G: A multinational cross-sectional study
by: Hand, R.M., et al.
Published: (2020)

Modelling and active control of the Vacuum Infusion Process for composites manufacture
by: Modi, Dhiren
Published: (2008)

Flow and heat transfer on a moving flat plate in a parallel stream with constant surface heat flux: a stability analysis
by: Ismail, Nurul Syuhada, et al.
Published: (2016)

Direct two-point block methods for solving nonstiff higher order Ordinary Differential Equations using Backward Difference formulation
by: Mohd Ijam, Hazizah
Published: (2014)

A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: New insights for improved secondary prophylaxis strategies
by: Hand, R.M., et al.
Published: (2019)

Safety of antiepileptic drugs in children and young people: a prospective cohort study
by: Egunsola, Oluwaseun, et al.
Published: (2018)

Sodium MRI: a new frontier in imaging in nephrology
by: Francis, Susan T., et al.
Published: (2017)

Experimental and Computational Studies of Incorporation of Cyano Transition Metal Complexes in Potassium Chloride Crystals
by: Carter, Damien, et al.
Published: (2003)

Two-center convergent close-coupling calculations for positron-lithium collisions
by: Lugovskoy, Andrey, et al.
Published: (2010)

Effects Of Washing With Potassium And Sodium Hydroxide Mixtures In The Development Of Rancidity In Black Tilapia (Oreochromis Mossambicus) Fillets And The Frying Oil
by: Yusoff, Anida
Published: (2003)

Effects of processing method, moisture content, and resin system on physical and mechanical properties of woven kenaf plant fiber composites
by: Sharba, Mohaiman Jaffar, et al.
Published: (2016)

Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection: A randomized, crossover, population pharmacokinetic study in healthy adult volunteers
by: Kado, J.H., et al.
Published: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ib36m08rl4nnjqvop6ij7tfpmf