Stability of benzylpenicillin for continuous intravenous infusions: An isotonic formulation for therapeutic use and a low-dose formulation for clinical trial

Stability of benzylpenicillin for continuous intravenous infusions: An isotonic formulation for therapeutic use and a low-dose formulation for clinical trial

Introduction: The objectives of this study were to develop a stability-indicating high performance liquid chromatography (HPLC) assay for benzylpenicillin (BPC) in pharmaceutical fluids, and to investigate the stability of (i) isotonic citrate-buffered BPC solutions at the clinically relevant concen...

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Bibliographic Details
Main Authors: Batty, Kevin, Page-Sharp, Madhu, Salman, S., Hla, T.K., Manning, L.
Format: Journal Article
Language:English
Published: 2022
Subjects:
Benzylpenicillin
HPLC (High-performance liquid chromatography)
Intravenous infusion
Sodium citrate
Stability
Drug Stability
Humans
Hypertonic Solutions
Infusions, Intravenous
Isotonic Solutions
Penicillin G
Sodium Citrate
Temperature
Online Access:http://hdl.handle.net/20.500.11937/88953

Internet

http://hdl.handle.net/20.500.11937/88953

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