The artemiside-artemisox-artemisone-m1 tetrad: Efficacies against blood stage p. falciparum parasites, dmpk properties, and the case for artemiside

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The artemiside-artemisox-artemisone-m1 tetrad: Efficacies against blood stage p. falciparum parasites, dmpk properties, and the case for artemiside

Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside obtained in one scalable synthetic step from dihydroartemisinin (DHA) and th...

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Bibliographic Details
Main Authors:	Gibhard, L., Coertzen, D., Reader, J., van der Watt, M.E., Birkholtz, L.M., Wong, H.N., Batty, Kevin, Haynes, R.K., Wiesner, L.
Format:	Journal Article
Language:	English
Published:	MDPI 2021
Subjects:	Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy antimalarial drugs artemisinins ACTs resistance amino-artemisinins pharmacokinetics metabolism C-max drug efficacy HIGH-THROUGHPUT ASSAY ANTIMALARIAL-DRUG DIHYDROARTEMISININ PHARMACOKINETICS ARTESUNATE RESISTANCE MALARIA BIOAVAILABILITY SUSCEPTIBILITY COMBINATION
Online Access:	http://hdl.handle.net/20.500.11937/88951

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