The artemiside-artemisox-artemisone-m1 tetrad: Efficacies against blood stage p. falciparum parasites, dmpk properties, and the case for artemiside

The artemiside-artemisox-artemisone-m1 tetrad: Efficacies against blood stage p. falciparum parasites, dmpk properties, and the case for artemiside

Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside obtained in one scalable synthetic step from dihydroartemisinin (DHA) and th...

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Bibliographic Details
Main Authors: Gibhard, L., Coertzen, D., Reader, J., van der Watt, M.E., Birkholtz, L.M., Wong, H.N., Batty, Kevin, Haynes, R.K., Wiesner, L.
Format: Journal Article
Language:English
Published: MDPI 2021
Subjects:
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
antimalarial drugs
artemisinins
ACTs
resistance
amino-artemisinins
pharmacokinetics
metabolism
C-max
drug efficacy
HIGH-THROUGHPUT ASSAY
ANTIMALARIAL-DRUG
DIHYDROARTEMISININ
PHARMACOKINETICS
ARTESUNATE
RESISTANCE
MALARIA
BIOAVAILABILITY
SUSCEPTIBILITY
COMBINATION
Online Access:http://hdl.handle.net/20.500.11937/88951

Internet

http://hdl.handle.net/20.500.11937/88951

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