High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin g injections in ethiopian children and adults with rheumatic heart disease

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High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin g injections in ethiopian children and adults with rheumatic heart disease

Introduction: Intramuscular benzathine penicillin G (BPG) injections are a cornerstone of secondary prophylaxis to prevent acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Uncer-tainties regarding inter-ethnic and preparation variability, and target exposure profiles of BPG injection a...

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Bibliographic Details
Main Authors:	Ketema, E.B., Gishen, N.Z., Hailu, A., Leul, A., Hadgu, A., Hagos, K., Berhane, S., Tsega, T., Page-Sharp, Madhu, Davis, T.M.E., Moore, Brioni, Batty, Kevin, Carapetis, J., Salman, S., Manning, L.
Format:	Journal Article
Language:	English
Published:	PUBLIC LIBRARY SCIENCE 2021
Subjects:	Science & Technology Life Sciences & Biomedicine Infectious Diseases Parasitology Tropical Medicine PROPHYLAXIS FEVER POPULATION ECHOCARDIOGRAPHY STREPTOCOCCI PREVENTION PREVALENCE PATTERN
Online Access:	http://hdl.handle.net/20.500.11937/88949

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