Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection: A randomized, crossover, population pharmacokinetic study in healthy adult volunteers

Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection: A randomized, crossover, population pharmacokinetic study in healthy adult volunteers

Background: Benzathine penicillin G has been used as monthly deep intramuscular (IM) injections since the 1950s for secondary prevention of acute rheumatic fever and rheumatic heart disease (RHD). Injection frequency and pain are major programmatic barriers for adherence, prompting calls for develop...

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Bibliographic Details
Main Authors: Kado, J.H., Salman, S., Henderson, R., Hand, R., Wyber, R., Page-Sharp, Madhu, Batty, Kevin, Carapetis, J., Manning, L.
Format: Journal Article
Language:English
Published: OXFORD UNIV PRESS 2020
Subjects:
Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
Microbiology
Pharmacology & Pharmacy
PENICILLIN-G
SEX-DIFFERENCES
PROPHYLAXIS
MANAGEMENT
ABSORPTION
PAIN
Online Access:http://hdl.handle.net/20.500.11937/88947

Internet

http://hdl.handle.net/20.500.11937/88947

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