Adipose Loss and Metabolic Disease Due to Seipin Deficiency: Systemic Versus Tissue Specific Effects
This thesis aimed to understand the molecular mechanisms via which BSCL2 disruption causes metabolic disease in congenital generalised lipodystrophy type 2. The results presented provide evidence that seipin has significant roles in adipose tissue, by regulating lipolysis, but also in pancreatic ß-c...
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| Format: | Thesis |
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Curtin University
2021
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| Online Access: | http://hdl.handle.net/20.500.11937/88906 |
| _version_ | 1848765108939915264 |
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| author | Roumane, Ahlima |
| author_facet | Roumane, Ahlima |
| author_sort | Roumane, Ahlima |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis aimed to understand the molecular mechanisms via which BSCL2 disruption causes metabolic disease in congenital generalised lipodystrophy type 2. The results presented provide evidence that seipin has significant roles in adipose tissue, by regulating lipolysis, but also in pancreatic ß-cells where it influences insulin secretion. This work also reveals an interaction between seipin and glucagon-like peptide 1 receptor. This thesis demonstrates the therapeutic potential of liraglutide to treat metabolic disease in CGL2 patients. |
| first_indexed | 2025-11-14T11:30:01Z |
| format | Thesis |
| id | curtin-20.500.11937-88906 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:30:01Z |
| publishDate | 2021 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-889062024-07-31T05:43:42Z Adipose Loss and Metabolic Disease Due to Seipin Deficiency: Systemic Versus Tissue Specific Effects Roumane, Ahlima This thesis aimed to understand the molecular mechanisms via which BSCL2 disruption causes metabolic disease in congenital generalised lipodystrophy type 2. The results presented provide evidence that seipin has significant roles in adipose tissue, by regulating lipolysis, but also in pancreatic ß-cells where it influences insulin secretion. This work also reveals an interaction between seipin and glucagon-like peptide 1 receptor. This thesis demonstrates the therapeutic potential of liraglutide to treat metabolic disease in CGL2 patients. 2021 Thesis http://hdl.handle.net/20.500.11937/88906 Curtin University fulltext |
| spellingShingle | Roumane, Ahlima Adipose Loss and Metabolic Disease Due to Seipin Deficiency: Systemic Versus Tissue Specific Effects |
| title | Adipose Loss and Metabolic Disease Due to Seipin Deficiency:
Systemic Versus Tissue Specific Effects |
| title_full | Adipose Loss and Metabolic Disease Due to Seipin Deficiency:
Systemic Versus Tissue Specific Effects |
| title_fullStr | Adipose Loss and Metabolic Disease Due to Seipin Deficiency:
Systemic Versus Tissue Specific Effects |
| title_full_unstemmed | Adipose Loss and Metabolic Disease Due to Seipin Deficiency:
Systemic Versus Tissue Specific Effects |
| title_short | Adipose Loss and Metabolic Disease Due to Seipin Deficiency:
Systemic Versus Tissue Specific Effects |
| title_sort | adipose loss and metabolic disease due to seipin deficiency:
systemic versus tissue specific effects |
| url | http://hdl.handle.net/20.500.11937/88906 |