Immune-mediated ECM depletion improves tumour perfusion and payload delivery

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Immune-mediated ECM depletion improves tumour perfusion and payload delivery

High extracellular matrix (ECM) content in solid cancers impairs tumour perfusion and thus access of imaging and therapeutic agents. We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds. We target the immune-modulating cytokine, tumour necrosis factor...

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Bibliographic Details
Main Authors:	Yeow, Y.L., Kotamraju, V.R., Wang, X., Chopra, M., Azme, N., Wu, J., Schoep, T.D., Delaney, D.S., Feindel, K., Li, J., Kennedy, K.M., Allen, W.M., Kennedy, B.F., Larma, I., Sampson, D.D., Mahakian, L.M., Fite, B.Z., Zhang, H., Friman, T., Mann, A.P., Aziz, F.A., Kumarasinghe, M.P., Johansson, M., Ee, H.C., Yeoh, G., Mou, L., Ferrara, K.W., Billiran, H., Ganss, R., Ruoslahti, E., Hamzah, Juliana
Format:	Journal Article
Language:	English
Published:	2019
Subjects:	extracellular matrix immune cells peptide solid tumour tumour necrosis factor alpha Animals Cell Line Cell Surface Display Techniques Contrast Media Extracellular Matrix Female Ferric Compounds Gadolinium Heterocyclic Compounds Humans Male Mice Nanoparticles Organometallic Compounds Tumor Necrosis Factor-alpha
Online Access:	http://purl.org/au-research/grants/nhmrc/1046507 http://hdl.handle.net/20.500.11937/88887

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