Immune-mediated ECM depletion improves tumour perfusion and payload delivery

Immune-mediated ECM depletion improves tumour perfusion and payload delivery

High extracellular matrix (ECM) content in solid cancers impairs tumour perfusion and thus access of imaging and therapeutic agents. We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds. We target the immune-modulating cytokine, tumour necrosis factor...

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Bibliographic Details
Main Authors: Yeow, Y.L., Kotamraju, V.R., Wang, X., Chopra, M., Azme, N., Wu, J., Schoep, T.D., Delaney, D.S., Feindel, K., Li, J., Kennedy, K.M., Allen, W.M., Kennedy, B.F., Larma, I., Sampson, D.D., Mahakian, L.M., Fite, B.Z., Zhang, H., Friman, T., Mann, A.P., Aziz, F.A., Kumarasinghe, M.P., Johansson, M., Ee, H.C., Yeoh, G., Mou, L., Ferrara, K.W., Billiran, H., Ganss, R., Ruoslahti, E., Hamzah, Juliana
Format: Journal Article
Language:English
Published: 2019
Subjects:
extracellular matrix
immune cells
peptide
solid tumour
tumour necrosis factor alpha
Animals
Cell Line
Cell Surface Display Techniques
Contrast Media
Extracellular Matrix
Female
Ferric Compounds
Gadolinium
Heterocyclic Compounds
Humans
Male
Mice
Nanoparticles
Organometallic Compounds
Tumor Necrosis Factor-alpha
Online Access:http://purl.org/au-research/grants/nhmrc/1046507
http://hdl.handle.net/20.500.11937/88887

Internet

http://purl.org/au-research/grants/nhmrc/1046507
http://hdl.handle.net/20.500.11937/88887

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