The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease

QR Code

The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease

This study established a regulatory role for the Wnt/ß-catenin pathway in liver progenitor cells (LPCs) in cell culture and in vivo models of non-alcoholic fatty liver disease and demonstrated a significant potential for therapeutic targeting of LPCs with the Wnt inhibitor PRI-724 to inhibit chronic...

Full description

Bibliographic Details
Main Author:	Shirolkar, Gayatri Dhananjay
Format:	Thesis
Published:	Curtin University 2021
Online Access:	http://hdl.handle.net/20.500.11937/86615

Similar Items

Wnt/ß-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis
by: Shirolkar, Gayatri, et al.
Published: (2018)

Lifestyle interventions for non-alcoholic fatty liver disease
by: Ahmed, Idris Adewale, et al.
Published: (2019)

Characterisation of liver progenitor cells and their microenvironment during chronic liver disease and hepatocarcinogenesis
by: Köhn, Julia
Published: (2016)

WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma
by: Rogers, H.A., et al.
Published: (2012)

Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer
by: Fifis, T., et al.
Published: (2014)

Deciphering the role of BMP4 signalling and gene regulation in the specification of human liver progenitor cells
by: Durczak, Paulina Maria
Published: (2023)

Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non-alcoholic fatty liver disease
by: Grove, Jane I., et al.
Published: (2018)

The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway
by: Tang, Yulan, et al.
Published: (2022)

Bile acids associate with specific gut microbiota, low-level alcohol consumption and liver fibrosis in patients with non-alcoholic fatty liver disease
by: Adams, L.A., et al.
Published: (2020)

The role of liver progenitor cells during liver regeneration, fibrogenesis and carcinogenesis.
by: Köhn-Gaone, J., et al.
Published: (2016)

Non-alcoholic fatty liver disease: Epidemiology and non-invasive assessment / Chan Wah Kheong
by: Chan, Wah Kheong
Published: (2014)

Understanding the Relationship between Iron and Lipid Metabolism in Non-alcoholic Fatty Liver Disease
by: Singh, Abhishek Kumar
Published: (2022)

Elucidation Of The Molecular Mechanisms Of Orthosiphon Aristatus Extract In Non-Alcoholic Fatty Liver Disease
by: Al Shehade, Salah Abd Alrazak
Published: (2023)

Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays
by: Berry, A., et al.
Published: (2014)

Liver progenitor cell interactions with the extracellular matrix
by: Zhu, C., et al.
Published: (2012)

Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescents
by: Ayonrinde, Oyekoya, et al.
Published: (2016)

Investigating the association between iron and lipid metabolism with relevance to non-alcoholic fatty liver disease
by: Kidman, Clinton James
Published: (2022)

Molecular biomarkers and genetic determinants of non-alcoholic fatty liver disease / Tan Hwa Li
by: Tan, Hwa Li
Published: (2019)

The role of ethnicity in the increased susceptibility to non-alcoholic fatty liver disease in people of Indian origin
by: Chalmers, Jane
Published: (2021)

The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD)
by: Yusoff, Khairiah Mat
Published: (2018)

The relation between retinoids and non-alcoholic fatty liver: a review
by: Buyong, Zunariah, et al.
Published: (2019)

Mechanism-based intervention in Non-Alcoholic Fatty Liver Disease: mapping the muscle-liver axis and exploring the effect of L-carnitine on liver fat, insulin sensitivity and mitochondrial energy kinetics
by: Thiagarajan, Prarthana
Published: (2021)

Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer
by: Coombs, G., et al.
Published: (2012)

Exploring the experience of people at-risk of Non-alcoholic Fatty Liver Disease in making and maintaining lifestyle changes
by: Mehta, Rhian Mehta
Published: (2024)

The effect of modified alternate day calorie restriction (MACR) on non-alcoholic fatty liver disease (NAFLD)
by: Johari, Muhammad Izzad
Published: (2017)

Mortality rate of alcoholic liver disease and risk of hospitalisation for alcoholic liver cirrhosis, alcoholic hepatitis, and alcoholic liver failure in Australia between 1993 and 2005
by: Liang, Wenbin, et al.
Published: (2010)

The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs)
by: Rogers, H.A., et al.
Published: (2013)

A Transcriptomic Signature of Mouse Liver Progenitor Cells
by: Passman, A., et al.
Published: (2016)

Correlation of liver elastography with lipid profile, liver function test, and HbA1c in type II diabetes with non-alcoholic fatty liver disease in Hospital Universiti Sains Malaysia
by: Subbramaniam, Subashini A/P
Published: (2016)

Cardiovascular disease, cancer and mortality among people with type 2 diabetes and alcoholic or non-alcoholic fatty liver disease hospital admission
by: Wild, Sarah H., et al.
Published: (2018)

Could we address the interplay between CD133, Wnt/β-Catenin, and TERT signaling pathways as a potential target for Glioblastoma therapy?
by: Behrooz, Amir Barzegar, et al.
Published: (2021)

The role of intramyocellular lipid content in the physiological changes observed in inactivity, exercise, and non-alcoholic fatty liver disease
by: Chivaka, Prince
Published: (2023)

Proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model
by: Wang, Jing, et al.
Published: (2024)

Non alcoholic fatty liver disease related hepatocellular carcinoma: A 7 years retrospective observation study
by: Woon, Yong Chin
Published: (2020)

Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury
by: Viebahn, C., et al.
Published: (2010)

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration
by: Elsegood, Caryn, et al.
Published: (2015)

Evaluation of the "Cellscreen" system for proliferation studies on liver progenitor cells
by: Viebahn, C., et al.
Published: (2006)

Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses
by: Tirnitz-Parker, Nina, et al.
Published: (2014)

Liver progenitor cells, cancer stem cells and hepatocellular carcinoma
by: Tirnitz-Parker, Nina, et al.
Published: (2012)

Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury
by: Knight, B., et al.
Published: (2005)

Cannot write session to /tmp/vufind_sessions/sess_gd4ii6ohhl3mu5l1un54tc4ee8