The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease
This study established a regulatory role for the Wnt/ß-catenin pathway in liver progenitor cells (LPCs) in cell culture and in vivo models of non-alcoholic fatty liver disease and demonstrated a significant potential for therapeutic targeting of LPCs with the Wnt inhibitor PRI-724 to inhibit chronic...
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| Format: | Thesis |
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Curtin University
2021
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| Online Access: | http://hdl.handle.net/20.500.11937/86615 |
| _version_ | 1848764848883630080 |
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| author | Shirolkar, Gayatri Dhananjay |
| author_facet | Shirolkar, Gayatri Dhananjay |
| author_sort | Shirolkar, Gayatri Dhananjay |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This study established a regulatory role for the Wnt/ß-catenin pathway in liver progenitor cells (LPCs) in cell culture and in vivo models of non-alcoholic fatty liver disease and demonstrated a significant potential for therapeutic targeting of LPCs with the Wnt inhibitor PRI-724 to inhibit chronic liver disease progression. |
| first_indexed | 2025-11-14T11:25:53Z |
| format | Thesis |
| id | curtin-20.500.11937-86615 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:25:53Z |
| publishDate | 2021 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-866152021-11-25T05:20:03Z The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease Shirolkar, Gayatri Dhananjay This study established a regulatory role for the Wnt/ß-catenin pathway in liver progenitor cells (LPCs) in cell culture and in vivo models of non-alcoholic fatty liver disease and demonstrated a significant potential for therapeutic targeting of LPCs with the Wnt inhibitor PRI-724 to inhibit chronic liver disease progression. 2021 Thesis http://hdl.handle.net/20.500.11937/86615 Curtin University fulltext |
| spellingShingle | Shirolkar, Gayatri Dhananjay The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease |
| title | The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease |
| title_full | The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease |
| title_fullStr | The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease |
| title_full_unstemmed | The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease |
| title_short | The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease |
| title_sort | role of wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease |
| url | http://hdl.handle.net/20.500.11937/86615 |