IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

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IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high (BN) versus low susceptibility (PVG) to experim...

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Bibliographic Details
Main Authors:	de Jong, E., Lauzon-Joset, J.F., Leffler, J., Serralha, M., Larcombe, Alexander, Christophersen, Claus, Holt, P.G., Strickland, D.H., Bosco, A.
Format:	Journal Article
Language:	English
Published:	FRONTIERS MEDIA SA 2021
Subjects:	Science & Technology Life Sciences & Biomedicine Immunology asthma exacerbation rhinovirus allergen immunomodulation IRF7 systems biology GROWTH-FACTOR-BETA ASTHMA EXACERBATIONS ADHESION MOLECULES IMMUNE-RESPONSES DENDRITIC CELLS RISK SUSCEPTIBILITY INFECTION SEVERITY ATOPY
Online Access:	http://purl.org/au-research/grants/nhmrc/1129996 http://hdl.handle.net/20.500.11937/86510

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