IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high (BN) versus low susceptibility (PVG) to experim...

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Bibliographic Details
Main Authors: de Jong, E., Lauzon-Joset, J.F., Leffler, J., Serralha, M., Larcombe, Alexander, Christophersen, Claus, Holt, P.G., Strickland, D.H., Bosco, A.
Format: Journal Article
Language:English
Published: FRONTIERS MEDIA SA 2021
Subjects:
Science & Technology
Life Sciences & Biomedicine
Immunology
asthma exacerbation
rhinovirus
allergen
immunomodulation
IRF7
systems biology
GROWTH-FACTOR-BETA
ASTHMA EXACERBATIONS
ADHESION MOLECULES
IMMUNE-RESPONSES
DENDRITIC CELLS
RISK
SUSCEPTIBILITY
INFECTION
SEVERITY
ATOPY
Online Access:http://purl.org/au-research/grants/nhmrc/1129996
http://hdl.handle.net/20.500.11937/86510

Internet

http://purl.org/au-research/grants/nhmrc/1129996
http://hdl.handle.net/20.500.11937/86510

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