Limited P-glycoprotein mediated efflux for anti-epileptic drugs.
A variety of anti-epileptic drugs (AEDs) were tested for their ability to be transported by P-glycoprotein (P-gp) through Caco-2 monolayers using bi-directional (apical (Ap) to basolateral (Bas), and Bas to Ap) studies. Transport rates were equivalent in both directions for vigabatrin, gabapentin, p...
| Main Authors: | , |
|---|---|
| Format: | Journal Article |
| Published: |
informa UK Ltd
2006
|
| Online Access: | http://hdl.handle.net/20.500.11937/8478 |