An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques

QR Code

An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques

© 2019 Mooranian et al. Type 2 diabetes (T2D) is characterised by β-cell damage and hyperglycaemia. The lipophilic drug, probucol, has shown significant β-cell protective and potential antidiabetic effects, which were enhanced by hydrophilic bile acid incorporation using taurocholic acid and che...

Full description

Bibliographic Details
Main Authors:	Mooranian, Armin, Zamani, Nassim, Takechi, Ryu, Luna, Giuseppe, Mikov, M., Goločorbin-Kon, S., Elnashar, Magdy, Arfuso, Frank, Al-Salami, Hani
Format:	Journal Article
Language:	English
Published:	PUBLIC LIBRARY SCIENCE 2019
Subjects:	Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics POTENTIAL ANTIDIABETIC DRUG BILE-ACID INSULIN SENSITIVITY DELIVERY MICROENCAPSULATION FORMULATION MICROCAPSULES MUSCLES STRESS
Online Access:	http://hdl.handle.net/20.500.11937/82373

Similar Items

Stability and Release Kinetics of an Advanced Gliclazide-Cholic Acid Formulation: The Use of Artificial-Cell Microencapsulation in Slow Release Targeted Oral Delivery of Antidiabetics
by: Mooranian, Armin, et al.
Published: (2014)

An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer
by: Mooranian, Armin, et al.
Published: (2014)

Potentials and Limitations of Bile Acids in Type 2 Diabetes Mellitus: Applications of Microencapsulation as a Novel Oral Delivery System
by: Negrulj, Rebecca, et al.
Published: (2013)

Hydrodynamic characterisation of macromolecules in cucurbits
by: Jiwani, Shahwar
Published: (2016)

Application of bile acids in drug formulation and delivery
by: Stojancevic, M., et al.
Published: (2014)

Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol
by: Mooranian, Armin, et al.
Published: (2014)

Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes
by: Mooranian, Armin, et al.
Published: (2014)

Pharmacological effects of nanoencapsulation of human-based dosing of probucol on ratio of secondary to primary bile acids in gut, during induction and progression of type 1 diabetes
by: Mooranian, Armin, et al.
Published: (2018)

Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: A Characterization Study
by: Mooranian, Armin, et al.
Published: (2014)

Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats
by: Al-Salami, Hani, et al.
Published: (2009)

Novel chenodeoxycholic acid-sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study
by: Mooranian, A., et al.
Published: (2015)

Eudragit®-based microcapsules of probucol with a gut-bacterial processed secondary bile acid
by: Mooranian, A., et al.
Published: (2018)

Microencapsulation of Bifidobacterium pseudocatenulatum G4 using natural matrices
by: Abdul Khalil, Khalilah
Published: (2012)

Microencapsulation of Betacyanin extract from amaranth
by: Chong, Pik Han
Published: (2015)

Properties of alginate-chitosan microcapsule containing tocotrienols in self-assembled pickering emulsion and its stability in yogurt
by: Tan, Phui Yee
Published: (2017)

Synthesis of microcapsules for carbon capture via needle-based droplet microfluidics
by: Yew, Maxine, et al.
Published: (2019)

Novel nano-encapsulation of probucol in microgels: scanning electron micrograph characterizations, buoyancy profiling, and antioxidant assay analyses
by: Mooranian, A., et al.
Published: (2018)

Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus
by: Mooranian, Armin
Published: (2018)

Species Classification and Molecular Studies of Bile Salt Hydrolase (BSH) Gene in Bifidobacterium Spp
by: Mustafa, Shuhaimi
Published: (2003)

Encapsulation of tamoxifen and magnetic nanoparticles in poly lactic acid using supercritical antisolvent process
by: Alias, Dalila
Published: (2020)

Nutrient regulation of insulin secretion and action
by: Newsholme, Philip, et al.
Published: (2014)

Optimization of Freeze-Drying Protectants by Response Surface Methodology and Encapsulation for Bifidobacterium Pseudocatenulatum G4 and Lactobacillus Acidophilus LA-5 Survival Enhancement
by: Teoh, Peck Lian
Published: (2011)

Optimization of process conditions and emulsion composition, and their effects on emulsion and encapsulation properties of spray-dried fish oil powder
by: Tirgar, Mina
Published: (2012)

Microencapsulated Nigella sativa L. oil as functional ingredient for non-dairy creamer
by: Mohammed, Nameer Khairullah
Published: (2018)

Use of Artificial Cell Microcapsule Containing Thalidomide for Treating TNBS-induced Crohn's Disease in Mice
by: Fakhoury, M., et al.
Published: (2014)

Swelling, mechanical strength, and release properties of probucol microcapsules with and without a bile acid, and their potential oral delivery in diabetes
by: Negrulj, R., et al.
Published: (2015)

The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: potential hypoglycaemic and anti-inflammatory effects
by: Mooranian, Armin, et al.
Published: (2018)

Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches.
by: Elnashar, Magdy, et al.
Published: (2020)

Characterisation of red palm oil microcapsule with solution-enhanced dispersion by supercritical carbon dioxide technology
by: Lee, Wan Jun
Published: (2018)

Effect of microencapsulation efficiency of maltodextrin produced from breadfruit and broken rice and its in vitro wound healing efficacy
by: Mohamed Amin, Zahiah
Published: (2015)

The role of Proline-Rich Homeodomain protein PRH/HHEX in cholangiocarcinoma
by: Ghouth, Nahlah
Published: (2024)

Investigating the bile acid mediated control of Clostridioides difficile infection
by: von Emloh, Louise
Published: (2024)

Antidiabetic effects and mechanisms of action of γ-conglutin from lupin seeds
by: Tapadia, Mrunmai, et al.
Published: (2021)

Probucol prevents blood–brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet
by: Mamo, John, et al.
Published: (2018)

Fabrication of high-stability Ni-PSF@PAO40 microcapsules and their lubricating properties in polyamide 6
by: Zhang, Wenli, et al.
Published: (2022)

Sodium alginate capsulation increased brain delivery of probucol and suppressed neuroinflammation and neurodegeneration
by: Mamo, J., et al.
Published: (2018)

Optimization of spray-drying process conditions for the production of maximally viable microencapsulated L. acidophilus NCIMB 701748
by: Behboudi-Jobbehdar, Solmaz, et al.
Published: (2013)

How reliable are case formulations?: a systematic literature review
by: Flinn, Lucinda, et al.
Published: (2015)

Data supporting development and validation of liquid chromatography tandem mass spectrometry method for the quantitative determination of bile acids in feces
by: Shafaei, A., et al.
Published: (2021)

PEM fuel cell multi-phase system
by: Hard, Kevin
Published: (2005)

Cannot write session to /tmp/vufind_sessions/sess_ievqktg93jc1ihn4oo12b78j25