The gut microbiota, environmental factors, and links to the development of food allergy
Food allergy appears to have its roots in an insufficient exposure to a diverse range of environmental microbiota during early life. Microbial exposure ensures the colonization of the gastrointestinal tract with commensal microbes, which is necessary for the induction of a balanced and tolerogenic i...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
BMC
2020
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/81557 |
| _version_ | 1848764386755215360 |
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| author | Lee, Khui Hung Song, Yong Wu, W. Yu, K. Zhang, Guicheng |
| author_facet | Lee, Khui Hung Song, Yong Wu, W. Yu, K. Zhang, Guicheng |
| author_sort | Lee, Khui Hung |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Food allergy appears to have its roots in an insufficient exposure to a diverse range of environmental microbiota during early life. Microbial exposure ensures the colonization of the gastrointestinal tract with commensal microbes, which is necessary for the induction of a balanced and tolerogenic immune function. High-throughput sequencing technology has facilitated in-depth studies of the gut microbiota as well as bacterial-derived metabolites. Although the role of the microbiota in allergies is now widely studied, its importance for food allergy was only recently noted. Studies in human cohorts have shown that there is an association of dysbiosis and pathogenesis of food allergy, while studies from animal models have demonstrated the capacity of specific species in the gut microbiota to alter immune response, which may lead to the desensitization of food allergy. This article reviews the role of the gut microbiota in food allergy, and discusses the influence of environmental factors as well as prevention and management strategies relating to such regulatory mechanism. |
| first_indexed | 2025-11-14T11:18:32Z |
| format | Journal Article |
| id | curtin-20.500.11937-81557 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:18:32Z |
| publishDate | 2020 |
| publisher | BMC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-815572020-11-04T02:03:20Z The gut microbiota, environmental factors, and links to the development of food allergy Lee, Khui Hung Song, Yong Wu, W. Yu, K. Zhang, Guicheng Environmental factors Food allergy Immune system Microbiota Probiotics Food allergy appears to have its roots in an insufficient exposure to a diverse range of environmental microbiota during early life. Microbial exposure ensures the colonization of the gastrointestinal tract with commensal microbes, which is necessary for the induction of a balanced and tolerogenic immune function. High-throughput sequencing technology has facilitated in-depth studies of the gut microbiota as well as bacterial-derived metabolites. Although the role of the microbiota in allergies is now widely studied, its importance for food allergy was only recently noted. Studies in human cohorts have shown that there is an association of dysbiosis and pathogenesis of food allergy, while studies from animal models have demonstrated the capacity of specific species in the gut microbiota to alter immune response, which may lead to the desensitization of food allergy. This article reviews the role of the gut microbiota in food allergy, and discusses the influence of environmental factors as well as prevention and management strategies relating to such regulatory mechanism. 2020 Journal Article http://hdl.handle.net/20.500.11937/81557 10.1186/s12948-020-00120-x eng http://creativecommons.org/licenses/by/4.0/ BMC fulltext |
| spellingShingle | Environmental factors Food allergy Immune system Microbiota Probiotics Lee, Khui Hung Song, Yong Wu, W. Yu, K. Zhang, Guicheng The gut microbiota, environmental factors, and links to the development of food allergy |
| title | The gut microbiota, environmental factors, and links to the development of food allergy |
| title_full | The gut microbiota, environmental factors, and links to the development of food allergy |
| title_fullStr | The gut microbiota, environmental factors, and links to the development of food allergy |
| title_full_unstemmed | The gut microbiota, environmental factors, and links to the development of food allergy |
| title_short | The gut microbiota, environmental factors, and links to the development of food allergy |
| title_sort | gut microbiota, environmental factors, and links to the development of food allergy |
| topic | Environmental factors Food allergy Immune system Microbiota Probiotics |
| url | http://hdl.handle.net/20.500.11937/81557 |