An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles
© 2016 The Authors. The highly restrictive blood-brain barrier (BBB) plays a critically important role in maintaining brain homeostasis and is pivotal for proper neuronal function. The BBB is currently considered the main limiting factor restricting the passage of large (up to 200 nm) intravenous...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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NATURE PUBLISHING GROUP
2016
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| Subjects: | |
| Online Access: | http://purl.org/au-research/grants/nhmrc/1028681 http://hdl.handle.net/20.500.11937/81495 |
| _version_ | 1848764377994362880 |
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| author | Smith, N.M. Gachulincova, I. Ho, D. Bailey, C. Bartlett, C.A. Norret, M. Murphy, J. Buckley, A. Rigby, P.J. House, M.J. Pierre, T.S. Fitzgerald, Melinda Iyer, K.S. Dunlop, S.A. |
| author_facet | Smith, N.M. Gachulincova, I. Ho, D. Bailey, C. Bartlett, C.A. Norret, M. Murphy, J. Buckley, A. Rigby, P.J. House, M.J. Pierre, T.S. Fitzgerald, Melinda Iyer, K.S. Dunlop, S.A. |
| author_sort | Smith, N.M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2016 The Authors.
The highly restrictive blood-brain barrier (BBB) plays a critically important role in maintaining brain homeostasis and is pivotal for proper neuronal function. The BBB is currently considered the main limiting factor restricting the passage of large (up to 200 nm) intravenously administered nanoparticles to the brain. Breakdown of the barrier occurs as a consequence of cerebrovascular diseases and traumatic brain injury. In this article, we report that remote injuries in the CNS are also associated with BBB dysfunction. In particular, we show that a focal partial transection of the optic nerve triggers a previously unknown transient opening of the mammalian BBB that occurs in the visual centres. Importantly, we demonstrate that this transient BBB breakdown results in a dramatic change in the biodistribution of intravenously administered large polymeric nanoparticles which were previously deemed as BBB-impermeable. |
| first_indexed | 2025-11-14T11:18:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-81495 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:18:24Z |
| publishDate | 2016 |
| publisher | NATURE PUBLISHING GROUP |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-814952020-11-03T01:53:21Z An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles Smith, N.M. Gachulincova, I. Ho, D. Bailey, C. Bartlett, C.A. Norret, M. Murphy, J. Buckley, A. Rigby, P.J. House, M.J. Pierre, T.S. Fitzgerald, Melinda Iyer, K.S. Dunlop, S.A. Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics CENTRAL-NERVOUS-SYSTEM SECONDARY DEGENERATION IN-VIVO NEUROLOGICAL DISEASES DELIVERY INJURY CONTRIBUTE TRANSPORT IMMUNE DRUGS © 2016 The Authors. The highly restrictive blood-brain barrier (BBB) plays a critically important role in maintaining brain homeostasis and is pivotal for proper neuronal function. The BBB is currently considered the main limiting factor restricting the passage of large (up to 200 nm) intravenously administered nanoparticles to the brain. Breakdown of the barrier occurs as a consequence of cerebrovascular diseases and traumatic brain injury. In this article, we report that remote injuries in the CNS are also associated with BBB dysfunction. In particular, we show that a focal partial transection of the optic nerve triggers a previously unknown transient opening of the mammalian BBB that occurs in the visual centres. Importantly, we demonstrate that this transient BBB breakdown results in a dramatic change in the biodistribution of intravenously administered large polymeric nanoparticles which were previously deemed as BBB-impermeable. 2016 Journal Article http://hdl.handle.net/20.500.11937/81495 10.1038/srep22595 English http://purl.org/au-research/grants/nhmrc/1028681 http://purl.org/au-research/grants/nhmrc/1087114 http://creativecommons.org/licenses/by/4.0/ NATURE PUBLISHING GROUP fulltext |
| spellingShingle | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics CENTRAL-NERVOUS-SYSTEM SECONDARY DEGENERATION IN-VIVO NEUROLOGICAL DISEASES DELIVERY INJURY CONTRIBUTE TRANSPORT IMMUNE DRUGS Smith, N.M. Gachulincova, I. Ho, D. Bailey, C. Bartlett, C.A. Norret, M. Murphy, J. Buckley, A. Rigby, P.J. House, M.J. Pierre, T.S. Fitzgerald, Melinda Iyer, K.S. Dunlop, S.A. An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles |
| title | An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles |
| title_full | An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles |
| title_fullStr | An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles |
| title_full_unstemmed | An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles |
| title_short | An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles |
| title_sort | unexpected transient breakdown of the blood brain barrier triggers passage of large intravenously administered nanoparticles |
| topic | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics CENTRAL-NERVOUS-SYSTEM SECONDARY DEGENERATION IN-VIVO NEUROLOGICAL DISEASES DELIVERY INJURY CONTRIBUTE TRANSPORT IMMUNE DRUGS |
| url | http://purl.org/au-research/grants/nhmrc/1028681 http://purl.org/au-research/grants/nhmrc/1028681 http://hdl.handle.net/20.500.11937/81495 |