Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury

QR Code

Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury

© 2020 Elsevier Inc. Secondary degeneration following an initial injury to the central nervous system (CNS) results in increased tissue loss and is associated with increasing functional impairment. Unilateral partial dorsal transection of the adult rat optic nerve (ON) has proved to be a useful expe...

Full description

Bibliographic Details
Main Authors:	Chiha, Wissam, Bartlett, C.A., Petratos, S., Fitzgerald, Melinda, Harvey, A.R.
Format:	Journal Article
Language:	English
Published:	ACADEMIC PRESS INC ELSEVIER SCIENCE 2020
Subjects:	Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Secondary degeneration Collapsin response mediator protein 2 Brain derived neurotrophic factor Retinal ganglion cells Adeno-associated viral vector Gene therapy CHRONIC SECONDARY DEGENERATION NEUROTROPHIC FACTOR GENE-THERAPY TRANSGENE EXPRESSION CONDUCTION-VELOCITY ACTION-POTENTIALS GROWTH-FACTOR CNS NEURONS TIME-COURSE ADULT-RATS
Online Access:	http://purl.org/au-research/grants/nhmrc/1087114 http://hdl.handle.net/20.500.11937/81493

Similar Items

Prevalence and genetic analyses of selected age-related macular degeneration-related polymorphisms and their responses to intravitreal ranibizumab
by: Mohamad, Nur Afiqah
Published: (2018)

Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats
by: Hodgetts, S.I., et al.
Published: (2018)

Molecular and cellular analysis of MSC-EPO-mediated protection of degenerating retinas
by: Koh, Avin Ee Hwan
Published: (2021)

An investigation of the epidemiology of age-related maculopathy in the UK
by: Wilde, Craig
Published: (2018)

Role of VEGF-A in chronic pain
by: Hulse, Richard P.
Published: (2017)

Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports
by: Kovac, Milomir, et al.
Published: (2017)

Role of NMNAT2 regulation in cortical primary neurons
by: Konstantoulaki, Katerina
Published: (2019)

Developing Mucous Penetrating Particles for Intestinal Gene Delivery using Non-viral GET Peptide System
by: Elnima, Alaa
Published: (2024)

Abrogation of oncogenic k-ras function by andrographolide derivatives via in silico, in vitro, and in vivo approaches
by: Quah, Shun Ying
Published: (2021)

Characterisation of erythropoietin gene-modified human mesenchymal stem cells and anti-apoptotic effect of glutamate excitotoxicity in a retinal neuron cell line
by: Shirley, Ding Suet Lee
Published: (2017)

Characterisation of a putative quorum sensing system in Colstridium difficile
by: Patel, Manisha R.
Published: (2011)

Intraperitoneal delivery of nanoparticles for cancer gene therapy
by: Hallaj-Nezhadi, Somayeh, et al.
Published: (2013)

MODIFIED CELL PENETRATING PEPTIDES FOR EFFICIENT POLYMER NANO/MICROPARTICLE DELIVERY FOR BONE DIFFERENTIATION APPLICATIONS
by: Jalal, Aveen
Published: (2020)

Targeted delivery of short hairpin RNA expressing plasmid using hepatitis B virus-like particle for bcl-2 gene silencing in cervical cancer cells
by: Akwiditya, Made Angga
Published: (2021)

Enhanced Raman sideband cooling of caesium atoms in a vapour-loaded magneto-optical trap
by: Li, Y., et al.
Published: (2015)

Neuroprotective effect of 7-geranyloxycinnamic acid isolated from Melicope lunu-ankenda (Gaertn.) T.G. hartley leaves in vitro
by: Mohamed, Mohamed, Zeinab Abdulwanis Masaoud
Published: (2020)

Hoxa9 collaborates with E2A-PBX1 in mouse B cell leukemia in association with Flt3 activation and decrease of B cell gene expression
by: Hassawi, Mona, et al.
Published: (2014)

NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo
by: Di Stefano, Michele, et al.
Published: (2017)

Optimisation of Delivery of the Ataxia Telangiectasia Mutated Transgene to HeLa Cells Using Glycosaminoglycan Enhanced Transduction
by: Siam, Ala'a
Published: (2021)

Investigating the Differential Regulation of Cell Surface GAG in Cancer: Using NGPD to Isolate Cancer Cell Specific Peptides
by: Hardie, Derek T.
Published: (2024)

Functionalising and Preserving Blood Platelets for Biologically Targeted Gene Therapies
by: Al athram, Nairouz
Published: (2025)

Epitranscriptomic Determinants of Aggressive Prostate Cancer
by: Haigh, Daisy
Published: (2021)

Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes
by: Shi, Wei, et al.
Published: (2017)

Research trends in microarray data analysis: modelling gene regulatory network by integrating transcription factors data / Farzana Kabir Ahmad and Siti Sakira Kamaruddin
by: Kabir Ahmad, Farzana, et al.
Published: (2015)

Phagocytes of the transected feline optic nerve: anultrastructural study
by: Chew, Stewart
Published: (2007)

Acute Cellular and Functional Changes With a Combinatorial Treatment of Ion Channel Inhibitors Following Spinal Cord Injury
by: O’Hare Doig, R.L., et al.
Published: (2020)

Secondary students' understanding of the gene concept : an analysis of conceptual change from multiple perspectives.
by: Venville, Grady J.
Published: (1997)

A Combined Recombinant Retroviral-Based Therapy for Colon Cancer in the Murine Model Using Anti-Tumorigenic and Anti-Angiogenic Agents
by: Nik Abd. Rahman, Nik Mohd. Afizan
Published: (2011)

Truncated chicken anemia virus-VP3 as a potential anti tumour vaccine
by: Lim, Shen Ni
Published: (2012)

Comparison of GIP and GLP-1 promoter-mediated insulin expression in Gut K and L-cells for the potential treatment of diabetes mellitus
by: Rasouli, Mina
Published: (2012)

Part A: Outlining the current state of AAVs & evaluating albumins potential role in AAV stability / Part B: Comparing separation resolution of multiple SEC columns & evaluating AAV-albumin interactions
by: Hughes, Oliver
Published: (2024)

Central visual field sensitivity data from microperimetry with spatially dense sampling
by: Astle, Andrew T., et al.
Published: (2016)

The effect of normal aging and age-related macular degeneration on perceptual learning
by: Astle, Andrew T., et al.
Published: (2015)

Electroimmunoblotting of myelin basic protein peptides: a novel approach to the rapid characterisation of antigenic specificities of monoclonal and polyclonal anti-MBP antibodies
by: Sheng, H.Z., et al.
Published: (1988)

Myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study
by: Kemp, A., et al.
Published: (2013)

The characterisation and interactions of biomedical polymers
by: Black, Fiona E.
Published: (1999)

Establishing and Utilising In Vitro Lung Models to Demonstrate Peptide Mediated Non-Viral Delivery
by: Smith, Lauren
Published: (2022)

Combination therapy using plasmid DNA-mediated VP3 and SHCD147 genes for colon cancer in a murine model
by: Ismail, Ruzila
Published: (2014)

Cardamonin from Alpinia rafflesiana Wall. ex Baker as inhibitor of inflammatory responses in IFN-Gamma/LPS-Stimulated microglial cell line (BV2) via NF-κB signalling pathway
by: Chow, Yuh Lit
Published: (2012)

Regulatory insight for a Zn2Cys6 transcription factor controlling effector-mediated virulence in a fungal pathogen of wheat
by: John, Evan, et al.
Published: (2024)

Cannot write session to /tmp/vufind_sessions/sess_p04t71bu0unmfi00on22hqjj96