Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury

Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury

© 2020 Elsevier Inc. Secondary degeneration following an initial injury to the central nervous system (CNS) results in increased tissue loss and is associated with increasing functional impairment. Unilateral partial dorsal transection of the adult rat optic nerve (ON) has proved to be a useful expe...

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Bibliographic Details
Main Authors: Chiha, Wissam, Bartlett, C.A., Petratos, S., Fitzgerald, Melinda, Harvey, A.R.
Format: Journal Article
Language:English
Published: ACADEMIC PRESS INC ELSEVIER SCIENCE 2020
Subjects:
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Secondary degeneration
Collapsin response mediator protein 2
Brain derived neurotrophic factor
Retinal ganglion cells
Adeno-associated viral vector
Gene therapy
CHRONIC SECONDARY DEGENERATION
NEUROTROPHIC FACTOR
GENE-THERAPY
TRANSGENE EXPRESSION
CONDUCTION-VELOCITY
ACTION-POTENTIALS
GROWTH-FACTOR
CNS NEURONS
TIME-COURSE
ADULT-RATS
Online Access:http://purl.org/au-research/grants/nhmrc/1087114
http://hdl.handle.net/20.500.11937/81493

Internet

http://purl.org/au-research/grants/nhmrc/1087114
http://hdl.handle.net/20.500.11937/81493

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