Acute Cellular and Functional Changes With a Combinatorial Treatment of Ion Channel Inhibitors Following Spinal Cord Injury

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Acute Cellular and Functional Changes With a Combinatorial Treatment of Ion Channel Inhibitors Following Spinal Cord Injury

Reducing the extent of secondary degeneration following spinal cord injury (SCI) is necessary to preserve function, but treatment options have thus far been limited. A combination of the ion channel inhibitors Lomerizine (Lom), YM872 and oxATP, to inhibit voltage-gated Ca2+ channels, Ca2+ permeable...

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Bibliographic Details
Main Authors:	O’Hare Doig, R.L., Santhakumar, S., Fehily, B., Raja, S., Solomon, T., Bartlett, C.A., Fitzgerald, Melinda, Hodgetts, S.I.
Format:	Journal Article
Language:	English
Published:	FRONTIERS MEDIA SA 2020
Subjects:	Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology spinal cord injury secondary degeneration ion channel inhibitors glia calcium (Ca2+) oxidative stress CHRONIC SECONDARY DEGENERATION OPTIC-NERVE TRANSECTION BETA-III TUBULIN BRILLIANT-BLUE-G OXIDATIVE STRESS SELECTIVE VULNERABILITY LIPID-PEROXIDATION TIME-COURSE CALCIUM-CHANNELS MOTOR-NEURONS
Online Access:	http://purl.org/au-research/grants/nhmrc/1061791 http://hdl.handle.net/20.500.11937/81492

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