Acute Cellular and Functional Changes With a Combinatorial Treatment of Ion Channel Inhibitors Following Spinal Cord Injury

Acute Cellular and Functional Changes With a Combinatorial Treatment of Ion Channel Inhibitors Following Spinal Cord Injury

Reducing the extent of secondary degeneration following spinal cord injury (SCI) is necessary to preserve function, but treatment options have thus far been limited. A combination of the ion channel inhibitors Lomerizine (Lom), YM872 and oxATP, to inhibit voltage-gated Ca2+ channels, Ca2+ permeable...

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Bibliographic Details
Main Authors: O’Hare Doig, R.L., Santhakumar, S., Fehily, B., Raja, S., Solomon, T., Bartlett, C.A., Fitzgerald, Melinda, Hodgetts, S.I.
Format: Journal Article
Language:English
Published: FRONTIERS MEDIA SA 2020
Subjects:
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
spinal cord injury
secondary degeneration
ion channel inhibitors
glia
calcium (Ca2+)
oxidative stress
CHRONIC SECONDARY DEGENERATION
OPTIC-NERVE TRANSECTION
BETA-III TUBULIN
BRILLIANT-BLUE-G
OXIDATIVE STRESS
SELECTIVE VULNERABILITY
LIPID-PEROXIDATION
TIME-COURSE
CALCIUM-CHANNELS
MOTOR-NEURONS
Online Access:http://purl.org/au-research/grants/nhmrc/1061791
http://hdl.handle.net/20.500.11937/81492

Internet

http://purl.org/au-research/grants/nhmrc/1061791
http://hdl.handle.net/20.500.11937/81492

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