Advances and perspectives in computational prediction of microbial gene essentiality

Advances and perspectives in computational prediction of microbial gene essentiality

Theminimal subset of genes required for cellular growth, survival and viability of an organismare classified as essential genes. Knowledge of essential genes gives insight into the core structure and functioning of a cell. Thismight lead tomore efficient antimicrobial drug discovery, to elucidation...

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Bibliographic Details
Main Authors: Mobegi, Fredrick, Zomer, A., de Jonge, M.I., van Hijum, S.A.F.T.
Format: Journal Article
Language:English
Published: OXFORD UNIV PRESS 2017
Subjects:
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Genetics & Heredity
gene essentiality prediction
computational methods
homology
transposons
next-generation sequencing
MULTIPLE SEQUENCE ALIGNMENT
GLOBAL TRANSPOSON MUTAGENESIS
CLUSTAL-W
GENOME
IDENTIFICATION
PHENOTYPE
NETWORK
RECONSTRUCTION
LOCALIZATION
OPTIMIZATION
Online Access:http://hdl.handle.net/20.500.11937/80734

Internet

http://hdl.handle.net/20.500.11937/80734

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