Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes

Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1, has previously been described. Inhibition of LS...

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Bibliographic Details
Main Authors: Smitheman, K.N., Severson, T.M., Rajapurkar, S.R., McCabe, M.T., Karpinich, N., Foley, J., Pappalardi, M.B., Hughes, A., Halsey, W., Thomas, E., Traini, C., Federowicz, K.E., Laraio, J., Mobegi, Fredrick, Ferron-Brady, G., Prinjha, R.K., Carpenter, C.L., Kruger, R.G., Wessels, L., Mohammad, H.P.
Format: Journal Article
Language:English
Published: FERRATA STORTI FOUNDATION 2019
Subjects:
Science & Technology
Life Sciences & Biomedicine
Hematology
HUMAN BONE-MARROW
SUPEROXIDE ANION
DISEASE
INHIBITION
NEUTROPHILS
APOPTOSIS
THERAPY
Online Access:http://hdl.handle.net/20.500.11937/80728

Internet

http://hdl.handle.net/20.500.11937/80728

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