Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

T-cell acute lymphoblastic leukemia (T-ALL) and T-cell acute lymphoblastic lymphoma (T-LBL) are aggressive hematological malignancies that are currently treated with high-dose chemotherapy. Over the last several years, the search toward novel and less-toxic therapeutic strategies for T-ALL/T-LBL pat...

Full description

Bibliographic Details
Main Authors: De Smedt, Renate, Morscio, Julie, Reunes, Lindy, Roels, Juliette, Bardelli, Valentina, Lintermans, Beatrice, Van Loocke, Wouter, Almeida, Afonso, Cheung, Laurence, Kotecha, Rishi, Mansour, Marc R, Uyttebroeck, Anne, Vandenberghe, Peter, La Starza, Roberta, Mecucci, Cristina, Lammens, Tim, Van Roy, Nadine, De Moerloose, Barbara, Barata, Joao T, Taghon, Tom, Goossens, Steven, Van Vlierberghe, Pieter
Format: Journal Article
Language:English
Published: AMER SOC HEMATOLOGY 2020
Subjects:
Science & Technology
Life Sciences & Biomedicine
Hematology
JAK/STAT PATHWAY INHIBITION
TRANSCRIPTIONAL REGULATION
SERINE/THREONINE KINASES
PROTEIN-KINASES
IL-7 RECEPTOR
MURINE
GROWTH
PHOSPHORYLATION
PROLIFERATION
PROMOTER
Online Access:http://purl.org/au-research/grants/nhmrc/1142627
http://hdl.handle.net/20.500.11937/79574

Internet

http://purl.org/au-research/grants/nhmrc/1142627
http://hdl.handle.net/20.500.11937/79574

Similar Items